|
rs13266634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, CMA suggested that rs13266634 protects against POHG directly and indirectly through its influence on liver steatosis and central adiposity.
|
31220282 |
2019 |
|
rs13361189
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our community-based, longitudinal cohort of Caucasian adults, variants in the autophagy-governing IRGM gene at the rs13361189 locus were not associated with increased prevalent or incident HS.
|
30597691 |
2019 |
|
rs1346324047
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of the V227A polymorphism is instead linked to a reduction of steatosis and raised γ-glutamyltranspeptidase levels in non-drinking Orientals, the latter being reduced in drinkers.
|
31489930 |
2019 |
|
rs1800234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of the V227A polymorphism is instead linked to a reduction of steatosis and raised γ-glutamyltranspeptidase levels in non-drinking Orientals, the latter being reduced in drinkers.
|
31489930 |
2019 |
|
rs3480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of the FNDC5 rs3480 minor (G) allele is associated with more severe steatosis in NAFLD through a microRNA-mediated mechanism controlling FNDC5 mRNA stability.
|
30389552 |
2019 |
|
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs6834314 was significantly associated with increased steatosis but decreased inflammation, ballooning, Mallory-Denk bodies, and liver enzyme levels in 768 adult Caucasians with biopsy-proven NAFLD and with cirrhosis in the general population.
|
30415504 |
2019 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs12785878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in the nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7 (rs3829251, rs12785878) and vitamin D receptor (rs2228570) genes were independently associated with increased steatosis; while a group-specific component variant (rs4588) was associated with increased inflammation in liver biopsies.
|
29761652 |
2018 |
|
rs1420472625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of the minor PNPLA3 p.I148M risk allele increased the risk of developing NAFLD (OR = 3.29, P < 0.001) and was associated with higher steatosis, fibrosis, and serum CK18-M30 levels (all P < 0.05).
|
29483677 |
2018 |
|
rs1800777
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant of the polymorphism rs1800777 of CETP gene is independently associated with the presence of steatosis and lobulillar inflammation in subjects with proven biopsy NAFLD.
|
30293065 |
2018 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in the nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7 (rs3829251, rs12785878) and vitamin D receptor (rs2228570) genes were independently associated with increased steatosis; while a group-specific component variant (rs4588) was associated with increased inflammation in liver biopsies.
|
29761652 |
2018 |
|
rs3829251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in the nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7 (rs3829251, rs12785878) and vitamin D receptor (rs2228570) genes were independently associated with increased steatosis; while a group-specific component variant (rs4588) was associated with increased inflammation in liver biopsies.
|
29761652 |
2018 |
|
rs4588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in the nicotinamide adenine dinucleotide synthase-1/dehydrocholesterol reductase-7 (rs3829251, rs12785878) and vitamin D receptor (rs2228570) genes were independently associated with increased steatosis; while a group-specific component variant (rs4588) was associated with increased inflammation in liver biopsies.
|
29761652 |
2018 |
|
rs641738
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, MBOAT7 rs641738 variants, neither heterozygous nor homozygous genotypes, were not associated with hepatic steatosis, insulin resistance, lipid levels and liver enzymes.
|
29314568 |
2018 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs72613567
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs72613567:TA variant was associated with a reduced risk of nonalcoholic steatohepatitis, but not steatosis, in human liver samples.
|
29562163 |
2018 |
|
rs772114791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This patient exhibited liver steatosis; he was neither diabetic, nor obese or alcoholic, but is a carrier of 2 polymorphisms, p.Ile148Met (rs738409) and p.Glu167Lys (rs58542926) on PNPLA3 and TM6SF2 gene, respectively, previously shown to be associated with nonalcoholic steatosis and fibrosis evolution.
|
28711549 |
2018 |
|
rs879254597
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This patient exhibited liver steatosis; he was neither diabetic, nor obese or alcoholic, but is a carrier of 2 polymorphisms, p.Ile148Met (rs738409) and p.Glu167Lys (rs58542926) on PNPLA3 and TM6SF2 gene, respectively, previously shown to be associated with nonalcoholic steatosis and fibrosis evolution.
|
28711549 |
2018 |
|
rs940553638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs1010023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast to their role in hepatic steatosis</span>, CC and TC genotypes of <i>PNPLA3</i> rs1010023 were correlated to significant improvement of homeostasis model assessment index (HOMA-IR) as compared to TT genotype in the CHB+HS group.
|
28695131 |
2017 |
|
rs1057972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under a dominant model, the rs1057972 polymorphism was associated with central obesity (P=0.045) and fatty liver (P=0.021), while the rs10833 polymorphism was associated with metabolic syndrome (P=0.007) in individuals with SA.
|
28923712 |
2017 |
|
rs10833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under a dominant model, the rs1057972 polymorphism was associated with central obesity (P=0.045) and fatty liver (P=0.021), while the rs10833 polymorphism was associated with metabolic syndrome (P=0.007) in individuals with SA.
|
28923712 |
2017 |
|
rs11591147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R46L variant associated with a two-fold increase prevalence of hepatic steatosis and higher epicardial fat thickness.
|
28758421 |
2017 |
|
rs3865188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conversely, the rs3865188 variant, associated with a lower OR for T2D, was also associated with lower BMI (P=0.03), HbA<sub>1c</sub> (P=0.02) and Fatty Liver Index (FLI; P≤0.01), and higher plasma adiponectin levels (P=0.002).
|
27289142 |
2017 |
|
rs951599607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genetic polymorphism I148M of the patatin-like phospholipase domain-containing 3 (PNPLA3) is associated with hepatic steatosis and its progression to steatohepatitis (NASH), fibrosis and cancer.
|
29116096 |
2017 |