|
rs1010023
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast to their role in hepatic steatosis</span>, CC and TC genotypes of <i>PNPLA3</i> rs1010023 were correlated to significant improvement of homeostasis model assessment index (HOMA-IR) as compared to TT genotype in the CHB+HS group.
|
28695131 |
2017 |
|
rs1014959895
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate analysis indicated that subjects with the heterozygous Gln27Glu mutant alleles had a significantly higher prevalence of fatty liver vs. those without the mutation (Glu27 allele frequency, 0.07 vs. 0.12, p=0.047; odds ratio, 1.92; 95% confidence interval, 1.01-3.68).
|
11718682 |
2001 |
|
rs1057972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under a dominant model, the rs1057972 polymorphism was associated with central obesity (P=0.045) and fatty liver (P=0.021), while the rs10833 polymorphism was associated with metabolic syndrome (P=0.007) in individuals with SA.
|
28923712 |
2017 |
|
rs10833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Under a dominant model, the rs1057972 polymorphism was associated with central obesity (P=0.045) and fatty liver (P=0.021), while the rs10833 polymorphism was associated with metabolic syndrome (P=0.007) in individuals with SA.
|
28923712 |
2017 |
|
rs1137100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LEPR rs1137100 is also associated with simple steatosis (OR 2.27, 95% CI 1.27-4.08, P = 0.006).
|
23278404 |
2013 |
|
rs11591147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R46L variant associated with a two-fold increase prevalence of hepatic steatosis and higher epicardial fat thickness.
|
28758421 |
2017 |
|
rs11669576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The only significant associations were found between LDL receptors exon8 c.1171G>A and METAVIR score or steatosis (P < 0.001).
|
26494968 |
2015 |
|
rs12137855
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We determined the frequency of PNPLA3 (rs738409), CSPG3/NCAN (rs2228603), GCKR (rs780094), PPP1R3B (rs4240624), TM6SF (rs8542926), LYPLAL1 (rs12137855) and MBOAT7 (rs626283) by RT-PCR in 117 HIV-positive patients on cART and stratified participants based on their "controlled attenuation parameter" (CAP) into probable (CAP: 215-300 dB/m) and definite (CAP >300 dB/m) hepatic steatosis.
|
28594920 |
2017 |
|
rs12137855
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated whether ultrasound-measured HS, with and without increased levels of alanine aminotransferase (ALT), or level of ALT alone, was associated with rs738409 (patatin-like phospholipase domain-containing protein 3 [PNPLA3]), rs2228603 (neurocan [NCAN]), rs12137855 (lysophospholipase-like 1), rs780094 (glucokinase regulatory protein [GCKR]), and rs4240624 (protein phosphatase 1, regulatory subunit 3b [PPP1R3B]) using regression modeling in an additive genetic model, controlling for age, age-squared, sex, and alcohol consumption.
|
23416328 |
2013 |
|
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Among polymorphisms, C677T, a thermolabile form, but not A1298C, thermostable, was associated with fatty liver and insulin resistance.
|
24488901 |
2014 |
|
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism may play a role in influencing liver fibrosis progression in patients with recurrent hepatitis C, in conjunction with donor age, but not via steatosis promotion.
|
17900242 |
2008 |
|
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the relation between liver steatosis with plasma homocysteine level and MTHFR C677T and A1298C polymorphisms in Brazilian patients with NAFLD.
|
23547829 |
2013 |
|
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In conclusion, a genetic background such as the MTHFR C677T polymorphism responsible for hyperhomocysteinemia plays a role in the development of higher degree of steatosis, which in turn accelerates the progression of liver fibrosis in CHC.
|
15834927 |
2005 |
|
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We aimed to assess the possible role of the MTHFR C677T mutation in the progression of simple steatosis to an advanced form of NAFLD.
|
17356914 |
2007 |
|
rs1217691063
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The presence of genotype TT of MTHFR C677T polymorphism was more common in CHC genotype non-1 infected patient regardless of histopathological classification and genotype TT+CT frequencies were significant in the presence of fibrosis grade 1+2 and of steatosis in CHC infected patients from the northeast of Brazil regardless of HCV genotype.
|
21854603 |
2011 |
|
rs121912666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, unlike the wt-p53, the Y220C mutant provides a specific protection against steatosis and potentially against its progression.
|
24395441 |
2014 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs1251713297
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1260326
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs1260326 was associated with elevated triglycerides (Caucasians P = 0.00014; African Americans P = 0.00417), large very low-density lipoprotein (VLDL) (Caucasians P = 0.001; African Americans, P = 0.03), and with fatty liver (Caucasians P = 0.034; African Americans P = 0.00002; and Hispanics P = 0.016).
|
22105854 |
2012 |
|
rs1260326
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Histological data showed significant association of GCKR rs1260326 with high steatosis grade (OR 1.76, 95 % CI 1.08-2.85, p = 0.04).
|
23800943 |
2014 |
|
rs1260326
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Metabolic effects of LYPLAL1 rs12137855-C were similar, but statistically less robust, to the effects of GCKR rs1260326-T. TM6SF2 rs58542926-T displayed opposite metabolic effects when compared with the fatty liver associations.
|
29648650 |
2018 |
|
rs1260326
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs12743824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12743824 and rs738491 SNPs were independently associated with FLD and steatohepatitis, respectively.
|
26352879 |
2015 |
|
rs12784396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nine variants (rs2862954, rs1408579, rs10883451, rs11597086, rs11591741, rs17729876, rs17668255, rs17668357, rs12784396) displayed genomewide significant associations at loci concomitantly influencing FL and ALT (2.47 × 10(-9) ≤ CMA-p ≤ 4.29 × 10(-10)) as compared with the suggestive significance of marginal tests (4.11 × 10(-5) ≤ GWA-p ≤ 2.34 × 10(-6)).
|
23477746 |
2013 |