|
rs17007417
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
|
29385134 |
2018 |
|
rs8099917
|
|
|
0.030 |
GeneticVariation |
BEFREE |
For HCV-genotype 1 patients, rs12980275 A and rs8099917 T alleles decreased the odds for liver steatosis (OR = 0.22; p < 0.001 and OR = 0.39; p = 0.048; respectively).
|
23103287 |
2013 |
|
rs8099917
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed.
|
24349054 |
2013 |
|
rs8099917
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Rs12979860 TT or rs8099917 GG genotypes as well as markers of serum and hepatocyte iron overload associated with higher activity of gamma-glutamyl transpeptidase and liver steatosis.
|
27125837 |
2017 |
|
rs12743824
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12743824 and rs738491 SNPs were independently associated with FLD and steatohepatitis, respectively.
|
26352879 |
2015 |
|
rs12980275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For HCV-genotype 1 patients, rs1</span>2980275 A and rs8099917 T alleles decreased the odds for liver steatosis (OR = 0.22; p < 0.001 and OR = 0.39; p = 0.048; respectively).
|
23103287 |
2013 |
|
rs13361189
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our community-based, longitudinal cohort of Caucasian adults, variants in the autophagy-governing IRGM gene at the rs13361189 locus were not associated with increased prevalent or incident HS.
|
30597691 |
2019 |
|
rs3865188
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Conversely, the rs3865188 variant, associated with a lower OR for T2D, was also associated with lower BMI (P=0.03), HbA<sub>1c</sub> (P=0.02) and Fatty Liver Index (FLI; P≤0.01), and higher plasma adiponectin levels (P=0.002).
|
27289142 |
2017 |
|
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs6834314 was significantly associated with increased steatosis but decreased inflammation, ballooning, Mallory-Denk bodies, and liver enzyme levels in 768 adult Caucasians with biopsy-proven NAFLD and with cirrhosis in the general population.
|
30415504 |
2019 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs2241766
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of the ADIPOQ rs2241766 G allele (GG/GT genotype) was associated with a protective effect against dyslipidemia, primarily in HIV/HCV-coinfected patients with steatosis.
|
24528335 |
2014 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate analysis indicated that subjects with the heterozygous Gln27Glu mutant alleles had a significantly higher prevalence of fatty liver vs. those without the mutation (Glu27 allele frequency, 0.07 vs. 0.12, p=0.047; odds ratio, 1.92; 95% confidence interval, 1.01-3.68).
|
11718682 |
2001 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs940553638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
rs1553403917
|
|
CA |
0.700 |
CausalMutation |
CLINVAR |
A Next Generation Sequencing custom gene panel as first line diagnostic tool for atypical cases of syndromic obesity: Application in a case of Alström syndrome.
|
29079548 |
2018 |
|
rs2854116
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The PNPLA3, but not the APOC3 rs2854116 SNP, was associated with fatty liver but not with triglyceride levels.
|
22105854 |
2012 |
|
rs2854116
|
|
|
0.020 |
GeneticVariation |
BEFREE |
By multivariable Cox analysis, concurrent fatty liver (HR 7.27, 95% confidence interval: 1.52-34.76; P = 0.013), age, cirrhosis, and APOC3 rs2854116 TC/CC genotype (HR 3.93, 95% confidence interval: 1.30-11.84; P = 0.013) were independent factors predicting HCC development.
|
27547913 |
2017 |
|
rs2070666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The APOC3 rs2070666 A allele was linked to the fourth quartile of the controlled attenuation parameter values (OR 2.769, 95 % CI 1.002-7.651) in 131 subjects, and also linked to the significant histological steatosis (OR 4.986, 95 % CI 1.020-24.371), but neither to liver stiffness measurement values nor to hepatic histological activity and fibrosis in NAFLD patients.
|
27059980 |
2016 |
|
rs74315468
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the relation between liver steatosis with plasma homocysteine level and MTHFR C677T and A1298C polymorphisms in Brazilian patients with NAFLD.
|
23547829 |
2013 |
|
rs886041065
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1800777
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant of the polymorphism rs1800777 of CETP gene is independently associated with the presence of steatosis and lobulillar inflammation in subjects with proven biopsy NAFLD.
|
30293065 |
2018 |
|
rs3213445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the rare CPT1b 66V (rs3213445) allele had significantly higher γ-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT) activities (P< 0·0001, P= 0·03 and P= 0·048, respectively) and a higher fatty liver index (FLI, P= 0·026).
|
22809552 |
2013 |
|
rs12784396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nine variants (rs2862954, rs1408579, rs10883451, rs11597086, rs11591741, rs17729876, rs17668255, rs17668357, rs12784396) displayed genomewide significant associations at loci concomitantly influencing FL and ALT (2.47 × 10(-9) ≤ CMA-p ≤ 4.29 × 10(-10)) as compared with the suggestive significance of marginal tests (4.11 × 10(-5) ≤ GWA-p ≤ 2.34 × 10(-6)).
|
23477746 |
2013 |
|
rs1554888939
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs2862954
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For example, the missense variant in ERLIN1-rs2862954 was genomewide significant (CMA-p = 4.88 × 10(-10)) for the combination of FL and ALT, while the respective univariate associations were suggestive (FL:p = 5.74 × 10(-6), ALT:p = 3.71 × 10(-6)).
|
23477746 |
2013 |