rs2896019
|
|
|
0.710 |
GeneticVariation |
BEFREE |
IL28B and PNPLA3 polymorphisms were associated with the presence of any steatosis (rs12979860, p = 1.87 × 10(-7); rs2896019, p = 7.56 × 10(-4)); clinically significant steatosis (rs12979860, p = 1.82 × 10(-3); rs2896019, p = 1.27 × 10(-4)); and steatosis severity (rs12979860, p = 2.05 × 10(-8); rs2896019, p = 2.62 × 10(-6)).
|
22543885 |
2012 |
rs2896019
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.
|
29385134 |
2018 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies of the PNPLA3 I148M</span> sequence variant in HCV infected individuals have reported an association between this variant and prevalence of steatosis, fibrosis, and cirrhosis.
|
22978414 |
2012 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 polymorphism was only significantly associated with risk of simple steatosis in the allele contrast and had no effect in the other genetic models.
|
25791171 |
2015 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In patients with NAFLD, adiponutrin rs738409 C-->G genotype, encoding for I148M, is associated with the severity of steatosis and fibrosis and the presence of nonalcoholic steatohepatitis.
|
20373368 |
2010 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 variant influences histological liver damage in Japanese patients with chronic hepatitis C. The G allele homozygotes are at higher risk for hepatic steatosis, severe necroinflammation, and advanced fibrosis.
|
25543233 |
2015 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the PNPLA3 p.I148M polymorphism influences steatosis and fibrogenesis in chronic hepatitis C (CHC).
|
22530607 |
2012 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of the PNPLA3 I148M protein variant (p.I148M) with steatosis, fibrosis stage, and cirrhosis was evaluated by logistic regression analysis.
|
22719190 |
2012 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis.
|
26389885 |
2015 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The presence of the minor PNPLA3 p.I148M risk allele increased the risk of developing NAFLD (OR = 3.29, P < 0.001) and was associated with higher steatosis, fibrosis, and serum CK18-M30 levels (all P < 0.05).
|
29483677 |
2018 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, IL28B rs12979860 and PNPLA3 rs738409 modify steatosis.
|
26259026 |
2016 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The influence of recipient and donor TM6SF2 genotypes, PNPLA3 rs738409 genotypes and nongenetic factors on the steatosis grade assessed 6 - 30 months after transplantation was analyzed by ordinal logistic regression.
|
31356578 |
2020 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 C > G single nucleotide polymorphism (SNP) has been associated with steatosis and fibrosis in previous NAFLD populations in which cirrhotic patients were very poorly represented.
|
27150500 |
2016 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 GG genotype is positively associated with HS, while the IFNL3 rs 12979860 CC genotype may be negatively associated with HS, in Asian CHC patients.
|
28797039 |
2017 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 GG genotype was associated with advanced fibrosis and steatosis, but not with HOMA-IR.
|
22634340 |
2012 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 PNPLA3 genotype influences steatosis development in CHC and is independently associated with cirrhosis and other steatosis-related clinical outcomes, such as lack of response to antiviral treatment and possibly HCC.
|
21319195 |
2011 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, its association with non-invasive ultrasound- and magnetic resonance (MR)-based markers of liver fibrosis and steatosis, the enhanced liver fibrosis (ELF) score, liver biopsy, as well as rs738409 in PNPLA3, has not been elucidated in NAFLD, so far.
|
28914407 |
2017 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a sequence variation within the gene encoding for patatin-like phospholipase containing 3 (PNPLA3, rs738409) was found to modulate steatosis, inflammation and fibrosis in NAFLD.
|
22884299 |
2013 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Donor PNPLA3 rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study.
|
29396131 |
2018 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
|
26599080 |
2015 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In children with NAFLD, the risk of severe steatosis is increased by SGA at birth, independent of and in addition to other powerful risk factors (insulin-resistance and I148M variant of the PNPLA3 gene).
|
28555633 |
2017 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis.
|
23808989 |
2013 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p.I148M variant leads to macrovescicular steaosis and predisposes to liver disorders from steatohepatitis to fibrosis.
|
30308089 |
2018 |
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis.
|
22087248 |
2011 |