Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Recently, a sequence variation within the gene encoding for patatin-like phospholipase containing 3 (PNPLA3, rs738409) was found to modulate steatosis, inflammation and fibrosis in NAFLD. 22884299

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer. 24222094

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis. 23808989

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed. 24349054

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Furthermore, the I148M variant represents a major determinant of progression of alcohol related steatohepatitis to cirrhosis, and to influence fibrogenesis and related clinical outcomes in chronic hepatitis C virus hepatitis, and possibly chronic hepatitis B virus hepatitis, hereditary hemochromatosis and primary sclerosing cholangitis. 24222941

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE In multivariate regression analysis, recipients who carried rs738409-GG had a 13.7-fold higher risk of graft steatosis than recipients who carried rs738409-CC (P = .022), independent of recipient age, weight gain after liver transplantation, or the underlying disease. 23872669

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1). 23275357

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE In CHB patients, the PNPLA3 I148M polymorphism influences susceptibility to steatosis and, in particular, when associated with severe overweight and alcohol intake, severe steatosis. 23564580

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The G allele of rs738409 (PNPLA3) and the T allele of rs780094 (GCKR) were associated with HS with a high level of ALT (odds ratio [OR], 1.36; P = .01; and OR, 1.30; P = .03, respectively). 23416328

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC. 23333103

2013

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis. 25250621

2014

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE As PNPLA3 I148M is a strong and inherited determinant of liver fat without affecting insulin resistance and lipid levels, these data suggest that steatosis has a causal role in determining serum Fetuin-A levels. 24828988

2014

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE SNP rs738409 in the adiponutrin gene (PNPLA3) is a well described factor for steatosis. 23870067

2014

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE CT-defined fatty liver is common among men at risk for HIV infection and is associated with greater visceral adiposity, HOMA-IR, and PNPLA3 (rs738409). 24642579

2014

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Carriage of the PNPLA3 rs738409 C >G polymorphism is not only associated with greater risk of progressive steatohepatitis and fibrosis but also of HCC. 24607626

2014

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE In this study, we show that only in subjects with hepatic steatosis, the OXFAs are associated with the CK-18 and that this association is modulated by the PNPLA3 rs738409 variant. 23815500

2014

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The rs738409 polymorphism was only significantly associated with risk of simple steatosis in the allele contrast and had no effect in the other genetic models. 25791171

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The PNPLA3 rs738409 variant influences histological liver damage in Japanese patients with chronic hepatitis C. The G allele homozygotes are at higher risk for hepatic steatosis, severe necroinflammation, and advanced fibrosis. 25543233

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis. 26389885

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection. 26599080

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The genetic polymorphism with an isoleucine-to-methionine substitution at position 148 (rs738409 C>G) in the patatin-like phospholipase domain protein 3 (PNPLA3) gene confers risk of steatosis. 25964223

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect. 25302781

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE Our aim was to assess the impact of PNPLA3 rs738409 G-allele on steatosis in HCV patients. 24927606

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The G-allele of PNPLA3 rs738409 was associated with NAFLD (odds ratio [OR] 1.55, 95% confidence interval 1.13-2.11, P = 0.006) and moderate-to-severe steatosis (OR 3.77, 95% confidence interval 1.78-7.98, P = 0.001) adjusted for age, sex, and BMI standard deviation score. 25522307

2015

dbSNP: rs738409
rs738409
0.100 GeneticVariation BEFREE The protective effect of statins on steatohepatitis was stronger in subjects not carrying the I148M PNPLA3 risk variant (p=0.02 for interaction), as statins were negatively associated with steatohepatitis in patients negative (p<0.001), but not in those positive for the I148M variant (p=n.s.). 25980762

2015