|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This gain of function provides a plausible biochemical mechanism for the development of liver steatosis in subjects carrying the I148M variant.
|
22560221 |
2012 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, a sequence variation within the gene encoding for patatin-like phospholipase containing 3 (PNPLA3, rs738409) was found to modulate steatosis, inflammation and fibrosis in NAFLD.
|
22884299 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recently, the common variant p.I148M of the enzyme adiponutrin (PNPLA3) has emerged as a major genetic determinant of hepatic steatosis and nonalcoholic steatohepatitis as well as its pathobiological sequelae fibrosis, cirrhosis, and hepatocellular cancer.
|
24222094 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The amount of abdominal fat can increase the association of PNPLA3 p.I148M with liver steatosis.
|
23808989 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association between PNPLA3 rs738409/IL28B rs8099917 genotypes and hepatic steatosis or liver fibrosis was observed.
|
24349054 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, the I148M variant represents a major determinant of progression of alcohol related steatohepatitis to cirrhosis, and to influence fibrogenesis and related clinical outcomes in chronic hepatitis C virus hepatitis, and possibly chronic hepatitis B virus hepatitis, hereditary hemochromatosis and primary sclerosing cholangitis.
|
24222941 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In multivariate regression analysis, recipients who carried rs738409-GG had a 13.7-fold higher risk of graft steatosis than recipients who carried rs738409-CC (P = .022), independent of recipient age, weight gain after liver transplantation, or the underlying disease.
|
23872669 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Herein, we aimed to study the association between hepatic fat accumulation as assessed by magnetic resonance imaging and circulating levels of cytokeratin-18 (CK-18) fragments, a robust NASH biomarker, and to explore the impact on this association of ethnicity, insulin resistance, and single nucleotide polymorphisms (SNPs) associated with steatosis (rs738409 in the PNPLA3, rs1260326 in the GCKR) or NASH severity (rs2645424 in the FDFT1).
|
23275357 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In CHB patients, the PNPLA3 I148M polymorphism influences susceptibility to steatosis and, in particular, when associated with severe overweight and alcohol intake, severe steatosis.
|
23564580 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G allele of rs738409 (PNPLA3) and the T allele of rs780094 (GCKR) were associated with HS with a high level of ALT (odds ratio [OR], 1.36; P = .01; and OR, 1.30; P = .03, respectively).
|
23416328 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 genetic variant in the patatin-like phospholipase domain-containing 3 (PNPLA3, adiponutrin) gene has been implicated as a genetic determinant of the entire spectrum of liver diseases, ranging from steatosis, chronic hepatitis, cirrhosis and ultimately to HCC.
|
23333103 |
2013 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, we genotyped the same patients for the patatin-like phospholipase-containing domain 3 (PNPLA3) I148M polymorphism, which is implicated in the development of liver steatosis.
|
25250621 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As PNPLA3 I148M is a strong and inherited determinant of liver fat without affecting insulin resistance and lipid levels, these data suggest that steatosis has a causal role in determining serum Fetuin-A levels.
|
24828988 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
SNP rs738409 in the adiponutrin gene (PNPLA3) is a well described factor for steatosis.
|
23870067 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
CT-defined fatty liver is common among men at risk for HIV infection and is associated with greater visceral adiposity, HOMA-IR, and PNPLA3 (rs738409).
|
24642579 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriage of the PNPLA3 rs738409 C >G polymorphism is not only associated with greater risk of progressive steatohepatitis and fibrosis but also of HCC.
|
24607626 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we show that only in subjects with hepatic steatosis, the OXFAs are associated with the CK-18 and that this association is modulated by the PNPLA3 rs738409 variant.
|
23815500 |
2014 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs738409 polymorphism was only significantly associated with risk of simple steatosis in the allele contrast and had no effect in the other genetic models.
|
25791171 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 variant influences histological liver damage in Japanese patients with chronic hepatitis C. The G allele homozygotes are at higher risk for hepatic steatosis, severe necroinflammation, and advanced fibrosis.
|
25543233 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A genetic variant in adiponutrin (PNPLA3) gene, rs738409 C/G, is associated with steatosis, severity, and progression of liver fibrosis in CHC patients, and predicts treatment outcome in difficult-to-cure HCV-infected patients with advanced fibrosis.
|
26389885 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Impact of PNPLA3 rs738409 SNP on Liver Fibrosis Progression, Portal Hypertension and Hepatic Steatosis in HIV/HCV Coinfection.
|
26599080 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genetic polymorphism with an isoleucine-to-methionine substitution at position 148 (rs738409 C>G) in the patatin-like phospholipase domain protein 3 (PNPLA3) gene confers risk of steatosis.
|
25964223 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A discrete trait analysis of NAFLD showed that rs58542926 was associated with a modest risk of fatty liver (P = 0.038; odds ratio [OR]: 1.37; 95% confidence interval [CI]: 1.02-1.84); nevertheless, conditioning on patatin-like phospholipase domain-containing 3 (PNPLA3)-rs738409 abolished this effect.
|
25302781 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our aim was to assess the impact of PNPLA3 rs738409 G-allele on steatosis in HCV patients.
|
24927606 |
2015 |
|
rs738409
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The G-allele of PNPLA3 rs738409 was associated with NAFLD (odds ratio [OR] 1.55, 95% confidence interval 1.13-2.11, P = 0.006) and moderate-to-severe steatosis (OR 3.77, 95% confidence interval 1.78-7.98, P = 0.001) adjusted for age, sex, and BMI standard deviation score.
|
25522307 |
2015 |