The remaining two gene-environment interactions were also identified in relation to ER- breast cancer risk and were found between 3p21-rs6796502 and age at menarche (OR<sub>int</sub> = 1.26, 95% CI: 1.12-1.43, p<sub>int</sub> =1.8 × 10<sup>-4</sup> ) and between 8q23-rs13267382 and age at first full-term pregnancy (OR<sub>int</sub> = 0.89, 95% CI: 0.83-0.95, p<sub>int</sub> = 5.2 × 10<sup>-4</sup> ).