Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs231775
rs231775
CTLA4
0.010 GeneticVariation BEFREE To detect Cytotoxic T- Lymphocyte Antigen-4 (CTLA4) single nucleotide polymorphisms (SNPs) at +49A/G (rs231775) and -318C/T (rs5742909) positions in children with idiopathic nephrotic syndrome (INS) and also assay urinary soluble CTLA4 (sCTLA4) levels in children with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) and steroid sensitive nephrotic syndrome (SSNS) in remission. 29968132

2019
dbSNP: rs5333
rs5333
EDNRA
0.010 GeneticVariation BEFREE Association of endothelin receptor type A rs5333 gene polymorphism with steroid response in Egyptian children with idiopathic nephrotic syndrome. 30672385

2019
dbSNP: rs5742909
rs5742909
CTLA4
0.010 GeneticVariation BEFREE To detect Cytotoxic T- Lymphocyte Antigen-4 (CTLA4) single nucleotide polymorphisms (SNPs) at +49A/G (rs231775) and -318C/T (rs5742909) positions in children with idiopathic nephrotic syndrome (INS) and also assay urinary soluble CTLA4 (sCTLA4) levels in children with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS) and steroid sensitive nephrotic syndrome (SSNS) in remission. 29968132

2019
dbSNP: rs1801274
rs1801274
FCGR2A
0.010 GeneticVariation BEFREE The FCGR2A rs1801274 SNP in the gene encoding the activating receptor CD32A confers susceptibility to idiopathic nephrotic syndrome. 29155175

2018
dbSNP: rs747126003
rs747126003
IL6 ; IL6-AS1
0.010 GeneticVariation BEFREE IL-6-G174C and TNFα-G308A polymorphisms may affect susceptibility to idiopathic nephrotic syndrome and might affect steroid response in INS patients. 29190601

2017
dbSNP: rs3842689
rs3842689
NR1I2
0.010 GeneticVariation BEFREE SXR rs3842689: a prognostic factor for steroid sensitivity or resistance in pediatric idiopathic nephrotic syndrome. 27377607

2016
dbSNP: rs1217691063
rs1217691063
MTHFR
0.010 GeneticVariation BEFREE We postulate that screening for factors such as factor V Leiden and MTHFR C677T mutation may be beneficial to patients associated with thromboembolism and idiopathic nephrotic syndrome. 18030499

2008
dbSNP: rs1045642
rs1045642
ABCB1
0.020 GeneticVariation BEFREE Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance. 28614261

2017
dbSNP: rs1045642
rs1045642
ABCB1
0.020 GeneticVariation BEFREE The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms 1236T>C, 2677T>G, and 3435T>C was studied in relation to susceptibility, demographics, and pathological characteristics, as well as their role in the therapeutic response (TR) to prednisone treatment in children with idiopathic nephrotic syndrome (INS). 25559283

2015
dbSNP: rs1128503
rs1128503
ABCB1
0.030 GeneticVariation BEFREE Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance. 28614261

2017
dbSNP: rs2032582
rs2032582
ABCB1
0.030 GeneticVariation BEFREE Studies have investigated rs1128503, rs1045642, and rs2032582 in multidrug resistance protein 1 (MDR1) for association with susceptibility to idiopathic nephrotic syndrome (INS) and steroid resistance. 28614261

2017
dbSNP: rs1128503
rs1128503
ABCB1
0.030 GeneticVariation BEFREE The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms 1236T>C, 2677T>G, and 3435T>C was studied in relation to susceptibility, demographics, and pathological characteristics, as well as their role in the therapeutic response (TR) to prednisone treatment in children with idiopathic nephrotic syndrome (INS). 25559283

2015
dbSNP: rs1128503
rs1128503
ABCB1
0.030 GeneticVariation BEFREE The purpose of the study was to investigate the distribution of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene and three exonic polymorphisms of the multidrug resistance 1 (MDR1) gene (C3435T, C1236T, and G2677T) in children diagnosed with idiopathic nephrotic syndrome (INS). 26154535

2015
dbSNP: rs2032582
rs2032582
ABCB1
0.030 GeneticVariation BEFREE The role of the multidrug resistance-1 (MDR1 or ABCB1) gene polymorphisms 1236T>C, 2677T>G, and 3435T>C was studied in relation to susceptibility, demographics, and pathological characteristics, as well as their role in the therapeutic response (TR) to prednisone treatment in children with idiopathic nephrotic syndrome (INS). 25559283

2015
dbSNP: rs2032582
rs2032582
ABCB1
0.030 GeneticVariation BEFREE The purpose of the study was to investigate the distribution of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene and three exonic polymorphisms of the multidrug resistance 1 (MDR1) gene (C3435T, C1236T, and G2677T) in children diagnosed with idiopathic nephrotic syndrome (INS). 26154535

2015
dbSNP: rs1272948499
rs1272948499
NPHS2
T 0.700 GeneticVariation CLINVAR Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management. 28117080

2017
dbSNP: rs1462028977
rs1462028977
NPHS2
A 0.700 CausalMutation CLINVAR Spectrum of mutations in Chinese children with steroid-resistant nephrotic syndrome. 28204945

2017
dbSNP: rs528833893
rs528833893
NPHS2
CA 0.700 CausalMutation CLINVAR Spectrum of mutations in Chinese children with steroid-resistant nephrotic syndrome. 28204945

2017
dbSNP: rs967339926
rs967339926
NPHS2 ; AXDND1
T 0.700 GeneticVariation CLINVAR Rapid Response to Cyclosporin A and Favorable Renal Outcome in Nongenetic Versus Genetic Steroid-Resistant Nephrotic Syndrome. 26668027

2016
dbSNP: rs1214047676
rs1214047676
NPHS2 ; AXDND1
0.700 GeneticVariation UNIPROT NPHS2 mutations account for only 15% of nephrotic syndrome cases. 26420286

2015
dbSNP: rs12240233
rs12240233
NPHS2
0.700 GeneticVariation UNIPROT NPHS2 mutations account for only 15% of nephrotic syndrome cases. 26420286

2015
dbSNP: rs1345260812
rs1345260812
NPHS2
0.700 GeneticVariation UNIPROT NPHS2 mutations account for only 15% of nephrotic syndrome cases. 26420286

2015
dbSNP: rs1490010141
rs1490010141
NPHS2 ; AXDND1
T 0.700 GeneticVariation CLINVAR A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. 25349199

2015
dbSNP: rs199506378
rs199506378
NPHS2 ; AXDND1
A 0.700 GeneticVariation CLINVAR A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. 25349199

2015
dbSNP: rs199506378
rs199506378
NPHS2 ; AXDND1
A 0.700 GeneticVariation CLINVAR Variability in phenotype induced by the podocin variant R229Q plus a single pathogenic mutation. 26413278

2015