| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.080 | GeneticVariation | BEFREE | In contrast, mutation analyses performed in parallel in melanocytic nevi of the eyelid identified BRAF V600E alterations in all 3 cases. | 29406329 | 2019 |
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0.080 | GeneticVariation | BEFREE | Improving classification of melanocytic nevi: Association of BRAF V600E expression with distinct histomorphologic features. | 29653212 | 2018 |
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0.080 | GeneticVariation | BEFREE | In the present study, the frequency of BRAF V600E mutation was evaluated in Russian patients with melanocytic lesions, of which 41.25% were primary melanoma and 60% were melanocytic nevi. | 25888143 | 2015 |
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0.080 | GeneticVariation | BEFREE | We found BRAF(V600E) mutations in the melanocytic nevi to be fully clonal, strongly suggesting that BRAF-activating mutations typically are early initiating events in melanocytic neoplasia. | 23690527 | 2013 |
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0.080 | GeneticVariation | BEFREE | However, using immunomagnetic separation or laser-capture microdissection, we examined BRAF mutations in sets of approximately 50 single cells isolated from acquired melanocytic nevi from 13 patients and found a substantial number of nevus cells that contained wild-type BRAF mixed with nevus cells that contained BRAF(V600E). | 19752400 | 2009 |
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0.080 | GeneticVariation | BEFREE | The V600E mutation was found in 0 (0%) of 13 samples diagnosed histologically as Spitz nevi, 9 (24.3%) of 37 invasive melanomas, and 5 (100%) of 5 other melanocytic nevi. | 17824790 | 2007 |
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0.080 | GeneticVariation | BEFREE | Differential gene expression in melanocytic nevi with the V600E BRAF mutation. | 17696195 | 2007 |
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0.080 | GeneticVariation | BEFREE | To investigate whether the frequency of the BRAF(V600E) (V-raf murine sarcoma virus oncogene homolog B1) mutation in melanocytic nevi is associated with sun exposure patterns, we examined 120 acquired melanocytic nevi excised from various anatomic sites, including glabrous skin, as well as 62 congenital nevi. | 16691193 | 2006 |