|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
|
24697361 |
2014 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
(3) regarding the subtypes of AITDs, patients with Graves' disease (GD) had a significant higher degree of C1858T polymorphism (TT vs. CC, OR=2.35, 95%CI=1.36˜4.05; TC vs. CC, OR=1.46, 95%CI=1.12˜1.89; TT/TC vs. CC, OR=1.54, 95%CI=1.33˜1.80; TT vs. TC/CC, OR=2.16, 95%CI=1.25˜3.72), while no association was observed in patients with Hashimoto's thyroiditis (HT).No publication bias was observed.
|
22374238 |
2012 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant difference in the distribution of the haplotype suggests that the PTPN22 gene rather than rs2476601 is involved in the development of AITD in the Japanese population.
|
20615141 |
2010 |
|
rs2476601
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD) and type I diabetes (T1D).
|
19090780 |
2009 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
rs3087243
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Furthermore, a joint analysis, with the INS and CTLA4 SNPs, revealed that CTLA4 rs3087243, ERBB3 rs2292399, and CLEC16A rs2903692, but not INS rs689, were significant risk factors for the cooccurrence of AITD in Japanese T1D.
|
18940880 |
2009 |
|
rs1061502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: <i>P</i> = 0.017, OR = 1.968; allele G: <i>P</i> = 0.018, OR = 1.946; rs1061502: AG genotype: <i>P</i> = 0.029, OR = 1.866; allele G: <i>P</i> = 0.031, OR = 1.847).
|
30774658 |
2019 |
|
rs1131665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that the AG genotype and the minor allele G frequency of rs1131665 and rs1061502 in AITD patients were both higher than those of the controls (rs1131665: AG genotype: <i>P</i> = 0.017, OR = 1.968; allele G: <i>P</i> = 0.018, OR = 1.946; rs1061502: AG genotype: <i>P</i> = 0.029, OR = 1.866; allele G: <i>P</i> = 0.031, OR = 1.847).
|
30774658 |
2019 |
|
rs12492609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the allele T of rs12492609 in <i>TMEM39A</i> was associated with AITD and Hashimoto's thyroiditis (HT) (<i>p</i> = 0.023; <i>p</i> = 0.028 respectively).
|
31553233 |
2019 |
|
rs13277113
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
rs17855750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206.
|
30694795 |
2019 |
|
rs2069550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Latitude and ethnicity significantly affected the association between rs2076740 and rs2069550 polymorphisms and AITD, indicating their protective effects in allele or dominant model (P = 0.012, 0.012, 0.012, 0.009, 0.009).
|
30139952 |
2019 |
|
rs2076740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Latitude and ethnicity significantly affected the association between rs2076740 and rs2069550 polymorphisms and AITD, indicating their protective effects in allele or dominant model (P = 0.012, 0.012, 0.012, 0.009, 0.009).
|
30139952 |
2019 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population.
|
30771152 |
2019 |
|
rs2736340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic variants of rs13277113 and rs2736340 of BLK were associated with susceptibility to GD, HT and AITD in an ethnic Chinese population.
|
30589937 |
2019 |
|
rs3761548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no allelic association of rs3761548 and rs3761549 polymorphisms with AITD susceptibility, albeit a significant difference in genotype distribution with respect to rs3761549.
|
30771152 |
2019 |
|
rs3761549
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no allelic association of rs3761548 and rs3761549 polymorphisms with AITD susceptibility, albeit a significant difference in genotype distribution with respect to rs3761549.
|
30771152 |
2019 |
|
rs7629750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the frequency of allele A at rs7629750 in AITD patients with onset age ≤18 years old was higher than that in AITD patients with onset age ≥19 (<i>p</i> = 0.046).
|
31553233 |
2019 |
|
rs853326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between rs2076740, rs2069550, and rs853326 polymorphisms and AITD risk is significantly affected by study characteristics.
|
30139952 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs1544410 polymorphism was associated with a reduced risk of AITD in European and African populations, but with an increased risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>VDR</i> rs2228570 polymorphism was associated with a reduced risk of AITD in Asian populations.
|
29765404 |
2018 |
|
rs2618431
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, compared with that in female controls, allele G of rs2618431 was increased in the female AITD patients.
|
30351170 |
2018 |
|
rs4840568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Allele A of rs4840568 linked to the susceptibility of the AITD teenagers.
|
30351170 |
2018 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The overall results indicated that <i>VDR</i> rs731236 and rs2228570 polymorphisms were significantly associated with a reduced risk of AITD.
|
29765404 |
2018 |
|
rs7574865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusion:</b> This meta-analysis showed a significant association between <i>STAT4</i> rs7574865 polymorphism and AITD susceptibility.
|
30666271 |
2018 |