The association of rs3129859 was robust in ACLF subgroups (ACLFs with liver cirrhosis, p=1.36×10<sup>-16</sup>; ACLFs without liver cirrhosis, p=1.52×10<sup>-7</sup>), and patients at low-replicative phase (p=6.36×10<sup>-11</sup>, OR=2.29) or HBV e antigen-negative chronic hepatitis B phase (p=1.51×10<sup>-14</sup>, OR=1.86).
Among 1300 ACLFs and 2087 AsCs, we identified r</span>s3129859 at human leucocyte antigen (HLA) class II region (chromosome 6p21.32) associated with HBV-related ACLF (combined P <i>