DisGeNET - a database of gene-disease associations

Head and Neck Carcinoma, C3887461

Variant: rs13181 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs13181

ERCC2 ; KLC3

0.040

GeneticVariation

BEFREE

However, no statistically significant association was observed between the risk of developing HNC and the ERCC2 Lys751Gln and ERCC3 A>G polymorphisms.

24020925

2014

dbSNP:

rs13181

ERCC2 ; KLC3

0.040

GeneticVariation

BEFREE

There is overall lack of association between XPD Lys751Gln polymorphism and HNC risk under all five genetic models and still no significant association was found in the subgroup analysis by ethnicity and source of controls.

24443924

2014

dbSNP:

rs13181

ERCC2 ; KLC3

0.040

GeneticVariation

BEFREE

In the present study we investigated the association between three polymorphisms of the MUTYH (Tyr165Cys, rs34612342), the OGG1 (Ser326Cys, rs1052133) and the XPD (Lys751Gln, rs13181) genes with head and neck cancer risk.

20571908

2011

dbSNP:

rs13181

ERCC2 ; KLC3

0.040

GeneticVariation

BEFREE

In conclusion, our meta-analysis demonstrated that XPD Lys751Gln polymorphism could be a prediction marker for risk of head and neck cancer.

22179996

2011