|
rs773442580
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated whether stable expression of an activated Ki-Ras oncogenic mutant (G12V) in human astrocytoma cells leads to constitutive activation of the MAP kinase pathway and how this may influence cellular proliferation and signaling by epidermal growth factor (EGF) receptor.
|
9863009 |
1999 |
|
rs1476157710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, an in vitro functional assay showed that S73F and S23G mutants of beta-catenin did not affect transcriptional activity in TCF-4-leuciferase reporter construct, suggesting that they may need more complex factors to participate in astrocytoma.
|
12049819 |
2002 |
|
rs371409680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine this issue, we analyzed the significance of sequential accumulation of two somatic point mutations (R267W and E258D) in the TP53 gene during the initiation of astrocytoma in a patient born with a single germ-line p53 point mutation (R283H).
|
12019170 |
2002 |
|
rs55832599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine this issue, we analyzed the significance of sequential accumulation of two somatic point mutations (R267W and E258D) in the TP53 gene during the initiation of astrocytoma in a patient born with a single germ-line p53 point mutation (R283H).
|
12019170 |
2002 |
|
rs766727892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, an in vitro functional assay showed that S73F and S23G mutants of beta-catenin did not affect transcriptional activity in TCF-4-leuciferase reporter construct, suggesting that they may need more complex factors to participate in astrocytoma.
|
12049819 |
2002 |
|
rs866419664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine this issue, we analyzed the significance of sequential accumulation of two somatic point mutations (R267W and E258D) in the TP53 gene during the initiation of astrocytoma in a patient born with a single germ-line p53 point mutation (R283H).
|
12019170 |
2002 |
|
rs867657798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, an in vitro functional assay showed that S73F and S23G mutants of beta-catenin did not affect transcriptional activity in TCF-4-leuciferase reporter construct, suggesting that they may need more complex factors to participate in astrocytoma.
|
12049819 |
2002 |
|
rs868162712
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, an in vitro functional assay showed that S73F and S23G mutants of beta-catenin did not affect transcriptional activity in TCF-4-leuciferase reporter construct, suggesting that they may need more complex factors to participate in astrocytoma.
|
12049819 |
2002 |
|
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We propose the three-hit hypothesis as a triangle initiators includes D1853N as a first predisposing hit, IVS 38- 63T --> A as a second hit deriving from the first somatic evolution before differentiation and IVS 38- 30 A --> G as a third hit through the development of an astrocytoma.
|
18465141 |
2008 |
|
rs121913499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IDH1 mutations of the R132C type are strongly associated with astrocytoma, while IDH2 mutations predominantly occur in oligodendroglial tumors.
|
19554337 |
2009 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined GSTP1 Ile105Val polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.
|
21128213 |
2010 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The BRAF(V600E) inhibitor PLX4720 significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells.
|
22586120 |
2012 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The BRAF(V600E) inhibitor PLX4720 significantly increased survival of mice after intracranial transplant of genetically relevant murine or human astrocytoma cells.
|
22586120 |
2012 |
|
rs58064122
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the basis of the protective role shown by both these small heat shock proteins (sHSPs), and on the already well established neuroprotective effects of curcumin in several diseases, we have investigated the effects of this compound in an in vitro model of Alexander disease, consisting in U251-MG astrocytoma cells transiently transfected with a construct encoding for GFAP carrying the p.R239C mutation in frame with the reporter green fluorescent protein (GFP).
|
22705585 |
2012 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined XRCC3 Thr241Met polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma samples.
|
22370935 |
2012 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244).
|
24132923 |
2013 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The BT-40 low-grade childhood astrocytoma xenograft model expresses mutated BRAF(V600E) and is highly sensitive to the MEK inhibitor selumetinib (AZD6244).
|
24132923 |
2013 |
|
rs2297440
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the recessive model, we found two tSNPs (rs2297440 and rs6010620) associated with increased astrocytoma risk.
|
23812731 |
2013 |
|
rs137852972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we show that expression of seipin N-glycosylation mutant N88S led to decreased triglyceride (TG) content in astrocytoma and motor neuron cell lines.
|
23250914 |
2013 |
|
rs2853676
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk.
|
23812731 |
2013 |
|
rs6010620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk.
|
23812731 |
2013 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
BRAF V600E mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells.
|
24354918 |
2014 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
BRAF V600E mutation was observed both in epithelioid tumor cells and in diffusely infiltrating less atypical astrocytoma cells.
|
24354918 |
2014 |