These results indicate that the <i>TP53</i> gene rs1042522 allele G may be a potential protective factor against neu</span>roblastoma in Chinese children.
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
In our stratification analysis of age, gender, sites of origin, and clinical stages, we observed that subjects with rs1042522 CG/GG genotypes had a lower risk of developing neuroblastoma in the mediastinum (Adjusted OR=0.52, 95% CI=0.33-0.82, <i>P</i>=0.005) than those carrying the CC genotype.