Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893877
rs104893877
0.050 GeneticVariation BEFREE In this study, we examined the influence of the overexpression of wild-type (WT) and mutant-type (MT, A53T and A30P) α-synuclein on the autophagy in neuroblastoma SH-SY5Y cells under starvation, and then investigated the regulation of endogenous HMGB1 on the α-synuclein degradation and on the starvation-induced autophagy in the α-synuclein-overexpressed SH-SY5Y cells. 29551576

2018

dbSNP: rs104893877
rs104893877
0.050 GeneticVariation BEFREE Finally, we show that this association inhibits α-synuclein A53T oligomer toxicity in neuroblastoma cells. 28102321

2017

dbSNP: rs104893877
rs104893877
0.050 GeneticVariation BEFREE Marked dysregulations of microbial defense factors Ifit3 and Rsad2 were consistently observed upon five analyses: (1) Pink1 <sup>-/-</sup> primary neurons in the first weeks after brain dissociation, (2) aged Pink1 <sup>-/-</sup> midbrain with transgenic A53T-alpha-synuclein overexpression, (3) human neuroblastoma cells with PINK1-knockdown and murine Pink1 <sup>-/-</sup> embryonal fibroblasts undergoing acute starvation, (4) triggering mitophagy in these cells with trifluoromethoxy carbonylcyanide phenylhydrazone (FCCP), and (5) subjecting them to pathogenic RNA-analogue poly(I:C). 28768533

2017

dbSNP: rs104893877
rs104893877
0.050 GeneticVariation BEFREE Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein. 16584840

2006

dbSNP: rs104893877
rs104893877
0.050 GeneticVariation BEFREE We investigated transcriptional changes in neuroblastoma cell lines transfected with either normal or mutant (A30P or A53T) alpha-synuclein using microarrays, with confirmation of selected genes by quantitative RT-PCR. 12716427

2003