|
rs104893878
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In this study, we examined the influence of the overexpression of wild-type (WT) and mutant-type (MT, A53T and A30P) α-synuclein on the autophagy in neuroblastoma SH-SY5Y cells under starvation, and then investigated the regulation of endogenous HMGB1 on the α-synuclein degradation and on the starvation-induced autophagy in the α-synuclein-overexpressed SH-SY5Y cells.
|
29551576 |
2018 |
|
rs104893878
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Additionally, the expression of A30P α-syn on neuroblastoma SH-SY5Y leads to decreased cell death triggered by the CM of activated glia, when compared to WT α-syn or control group.
|
26502720 |
2015 |
|
rs104893878
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We used dopaminergic human neuroblastoma BE(2)-M17 cell lines stably transfected with WT or A30P mutant alpha-synuclein to characterize the effect of alpha-synuclein on dopamine toxicity.
|
20334701 |
2010 |
|
rs104893878
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.
|
19457084 |
2009 |
|
rs104893878
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The present study shows that overexpression of alpha-synuclein A53T or A30P mutants or wild-type in human neuroblastoma cells augmented aggregation of alpha-synuclein.
|
19460457 |
2009 |
|
rs104893878
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We investigated transcriptional changes in neuroblastoma cell lines transfected with either normal or mutant (A30P or A53T) alpha-synuclein using microarrays, with confirmation of selected genes by quantitative RT-PCR.
|
12716427 |
2003 |
|
rs104893877
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In this study, we examined the influence of the overexpression of wild-type (WT) and mutant-type (MT, A53T and A30P) α-synuclein on the autophagy in neuroblastoma SH-SY5Y cells under starvation, and then investigated the regulation of endogenous HMGB1 on the α-synuclein degradation and on the starvation-induced autophagy in the α-synuclein-overexpressed SH-SY5Y cells.
|
29551576 |
2018 |
|
rs104893877
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Finally, we show that this association inhibits α-synuclein A53T oligomer toxicity in neuroblastoma cells.
|
28102321 |
2017 |
|
rs104893877
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Marked dysregulations of microbial defense factors Ifit3 and Rsad2 were consistently observed upon five analyses: (1) Pink1 <sup>-/-</sup> primary neurons in the first weeks after brain dissociation, (2) aged Pink1 <sup>-/-</sup> midbrain with transgenic A53T-alpha-synuclein overexpression, (3) human neuroblastoma cells with PINK1-knockdown and murine Pink1 <sup>-/-</sup> embryonal fibroblasts undergoing acute starvation, (4) triggering mitophagy in these cells with trifluoromethoxy carbonylcyanide phenylhydrazone (FCCP), and (5) subjecting them to pathogenic RNA-analogue poly(I:C).
|
28768533 |
2017 |
|
rs104893877
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Neuroblastoma cells were stably transfected with wild type (WT) and A53T mutant alpha-synuclein.
|
16584840 |
2006 |
|
rs104893877
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We investigated transcriptional changes in neuroblastoma cell lines transfected with either normal or mutant (A30P or A53T) alpha-synuclein using microarrays, with confirmation of selected genes by quantitative RT-PCR.
|
12716427 |
2003 |
|
rs17016074
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of SNP rs17016074 increased luciferase expression by 32% in a transient transfection assay in SHSY5Y neuroblastoma cells.
|
19540308 |
2009 |