|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results indicate that the <i>TP53</i> gene rs1042522 allele G may be a potential protective factor against neu</span>roblastoma in Chinese children.
|
30719141 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
|
31325764 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In our stratification analysis of age, gender, sites of origin, and clinical stages, we observed that subjects with rs1042522 CG/GG genotypes had a lower risk of developing neuroblastoma in the mediastinum (Adjusted OR=0.52, 95% CI=0.33-0.82, <i>P</i>=0.005) than those carrying the CC genotype.
|
28275206 |
2017 |
|
rs1131691014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
|
31325764 |
2019 |
|
rs878854066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
|
31325764 |
2019 |
|
rs121912664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data indicate that in addition to adrenocortical tumors, choroid plexus carcinoma, breast cancer and osteosarcoma, genetic counseling and clinical surveillance should consider neuroblastoma as a potential neoplasia affecting p.R337H carriers.
|
26452166 |
2015 |
|
rs35850753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report on the analysis of three independent case-control cohorts comprising 10290 individuals and demonstrate that rs78378222 and rs35850753, rare germline variants in linkage disequilibrium that map to the 3' untranslated region (UTR) of TP53 and 5' UTR of the Δ133 isoform of TP53, respectively, are robustly associated with neuroblastoma (rs35850753: odds ratio [OR] = 2.7, 95% confidence interval [CI] = 2.0 to 3.6, P combined = 3.43×10(-12); rs78378222: OR = 2.3, 95% CI = 1.8 to 2.9, P combined = 2.03×10(-11)).All statistical tests were two-sided.
|
24634504 |
2014 |
|
rs78378222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings add neuroblastoma to the complex repertoire of human cancers influenced by the rs78378222 hypomorphic allele, which impairs proper termination and polyadenylation of TP53 transcripts.
|
24634504 |
2014 |
|
rs121912651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It remains unclear at this time whether a similar association of NB and R248W in patients with LFS exists.
|
17427234 |
2008 |
|
rs786203436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Nevertheless, the G81A/C91T polymorphism, previously implicated in regulating the expression of p73, did not show any significant association with neuroblastoma development.
|
11205839 |
2001 |