Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs33939927
rs33939927
LRRK2
0.060 GeneticVariation BEFREE On the other hand, the constitutive mutant of LRRK2(R1441G), known to cause PD, leads to down-regulation of the same pathway. 23600457

2013
dbSNP: rs33939927
rs33939927
LRRK2
0.060 GeneticVariation BEFREE In addition, introduction of miR-205 prevented the neurite outgrowth defects in the neurons expressing a PD-related LRRK2 R1441G mutant. 23125283

2013
dbSNP: rs33939927
rs33939927
LRRK2
0.060 GeneticVariation BEFREE LRRK2 G2019S and R1441C mutations associated with PD were not an uncommon mutation in a Sardinian population, especially in sporadic PD patients. 18805725

2009
dbSNP: rs33939927
rs33939927
LRRK2
0.060 GeneticVariation BEFREE Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease. 18337586

2008
dbSNP: rs33939927
rs33939927
LRRK2
0.060 GeneticVariation BEFREE Pathogenic substitutions in the leucine-rich repeat kinase 2 protein (Lrrk2), R1441G and G2019S, are a prevalent cause of autosomal dominant and sporadic Parkinson's disease in the Northern Spanish population. 17614198

2007
dbSNP: rs33939927
rs33939927
LRRK2
0.060 GeneticVariation BEFREE Notably, one single mutation in this gene (R1441G) not only appeared in familial, but also in apparently sporadic Parkinson disease (PD) patients of Basque descent. 16991141

2006