| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | BEFREE | We find that structure-based and PD-associated disease mutations in the WD40 domain including the common G2385R polymorphism mainly compromise dimer formation. | 30635421 | 2019 |
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0.090 | GeneticVariation | BEFREE | LRRK2 p.G2385R is an Asian specific genetic risk factor for sporadic Parkinson's disease. | 29414410 | 2018 |
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0.090 | GeneticVariation | BEFREE | Considering that there is overlap of the clinical manifestations and pathological characteristics between PD and MSA, we studied the possible associations between R1628P and G2385R polymorphisms of the LRRK2 and MSA in a population of Han Chinese patients. | 25511328 | 2015 |
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0.090 | GeneticVariation | BEFREE | Association between G2385R and R1628P polymorphism of LRRK2 gene and sporadic Parkinson's disease in a Han-Chinese population in south-eastern China. | 23624603 | 2013 |
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0.090 | GeneticVariation | BEFREE | LRRK2 Gly2385Arg polymorphism, cigarette smoking, and risk of sporadic Parkinson's disease: a case-control study in Japan. | 20673920 | 2010 |
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|
0.090 | GeneticVariation | BEFREE | The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population. | 19854095 | 2010 |
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0.090 | GeneticVariation | BEFREE | The c.G4883C variant in the leucine-rich repeat kinase 2 (LRRK2) gene (protein effect: Arg1628Pro) has been recently proposed as a second risk factor for sporadic Parkinson's disease in the Han Chinese population (after the Gly2385Arg variant). | 18716801 | 2008 |
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0.090 | GeneticVariation | BEFREE | LRRK2 low-penetrance mutations (Gly2019Ser) and risk alleles (Gly2385Arg)-linking familial and sporadic Parkinson's disease. | 17440812 | 2007 |
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|
0.090 | GeneticVariation | BEFREE | Our results suggest that the G2385R variant is a risk factor for sporadic Parkinson disease in the Asian population. | 17314670 | 2007 |