Our results suggest that women harboring the single nucleotide polymorphism <i>DNMT 3B</i> rs2424913 have a decreased risk of a DS pregnancy, and further studies are necessary to confirm this protective effect.
Considering this hypothesis we investigated the association of single nucleotide polymorphisms in the promoter region of the DNMT3B gene (rs1569686 -579G>T; rs2424913 -149C>T) with a predisposition of mothers to deliver a Down syndrome (DS) child.