|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs4986791
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Thr399Ile also may be connected with gallbladder cancer, and both of these polymorphisms apparently have no impact on risk of prostate cancer.
|
21081146 |
2011 |
|
rs4986791
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single locus analysis by logistic regression showed association of MSH2 IVS1+9G>C (rs2303426), ERCC2 Asp312Asn (rs1799793), OGG1 Ser326Cys (rs1052133), OGG1 IVS4-15C>G (rs2072668), CASP8 -652 6N ins/del (rs3834129), PTGS2 -1195G>A (rs689466), PTGS2 -765G>C (rs20417), TLR4 Ex4+936C>T (rs4986791) and TLR2 -196 to -174del polymorphisms with GBC risk.
|
21283657 |
2011 |
|
rs4986791
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The TLR4 Ex4+936C >T polymorphism (g.14143C>T; rs4986791) was also found to be significantly associated with the overall higher risk of GBC under a dominant mode of inheritance (OR=1.96; 95% CI=1.11-2.26; P(trend)=0.021).
|
20492496 |
2010 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs2695121
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single locus analysis showed association of MMP-2 (-735 C > T, -1306 C > T), MMP-7 - 181 A > G, MMP-9 (P574R, R668Q), TIMP-2 - 418 G > C, CYP1A1-MspI, CYP1A1-Ile462Val, PLCE1 (rs2274223 A > G, rs7922612 T > C) and LXR-beta T > C (rs3546355 G > A, rs2695121 T > C) polymorphisms with GBC risk (p < 0.05) whereas CYP1B1 and LXR-α variants were not associated with GBC risk.
|
24863943 |
2014 |
|
rs2695121
|
|
|
0.020 |
GeneticVariation |
BEFREE |
LXR-β genotypes (rs35463555) [GA + AA] and (rs2695121) [TC + CC] were associated with risk of GBC [OR = 1.46, p = 0.03; OR = 1.52, p = 0.01, respectively] as compared to healthy controls whereas LXR-α (rs7120118) was not associated with GBC risk.
|
23838803 |
2013 |
|
rs11887534
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Carriers of the CG genotype of ABCG8 rs11887534 had higher risk of biliary stones [odds ratio (OR) = 2.3, 95% confidence interval (CI) 0.82-6.5), gallbladder cancer (OR = 4.3, 95% CI 1.7-10.4) and bile duct cancer (OR = 1.94, 95% CI 0.64-5.91), compared with carriers of the GG genotype.
|
21062971 |
2011 |
|
rs20417
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single locus analysis by logistic regression showed association of MSH2 IVS1+9G>C (rs2303426), ERCC2 Asp312Asn (rs1799793), OGG1 Ser326Cys (rs1052133), OGG1 IVS4-15C>G (rs2072668), CASP8 -652 6N ins/del (rs3834129), PTGS2 -1195G>A (rs689466), PTGS2 -765G>C (rs20417), TLR4 Ex4+936C>T (rs4986791) and TLR2 -196 to -174del polymorphisms with GBC risk.
|
21283657 |
2011 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1052133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Results suggest that Cys/Cys genotype of OGG1 Ser326Cys polymorphism is associated with increased risk of GBC.
|
19266243 |
2009 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs11887534
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results suggest that the DH genotype and the H allele of the ABCG8 D19H polymorphism are associated with GBC susceptibility.
|
19018975 |
2009 |
|
rs20417
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We aimed to evaluate the role of PTGS2 -1195G>A [reference sequence (rs) 689466], -765G>C (rs20417) and +8473T>C (rs5275) polymorphisms in conferring interindividual susceptibility to gallbladder cancer.
|
19455278 |
2009 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We therefore tested associations between CYP1A1 T3801C, CYP1A1 Ile462Val, GSTM1deletion, and TP53 Arg72Pro and GBC in Hungary.
|
18990008 |
2009 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs1052133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that hOGG1 Ser326Cys polymorphism is associated with gallbladder cancer</span> risk.
|
17417784 |
2007 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs878854066
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that the Val allele of CYP1A1 Ile462Val polymorphism and the Pro allele of TP53 Arg72Pro polymorphism contribute to an increased risk of GBC among Japanese women and men, respectively.
|
17531965 |
2007 |
|
rs28934571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gallbladder cancer does not appear associate with the R249S mutation in TP53.
|
28428144 |
2017 |
|
rs104886003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in exons 9 (E542K, E545G, E545K) and 20 (H1047L and H1047R) of PI3K were determined by direct sequencing in 130 cases of GBC.
|
26947513 |
2016 |
|
rs1126497
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In GMDR analysis, ALCAM rs1157G>A, EpCAM rs1126497T>C emerged as best significant interaction model with GBC susceptibility and ALDH1A1 rs13959T>G with increased risk of grade 3-4 hematological toxicity.
|
26318430 |
2016 |
|
rs1157
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In GMDR analysis, ALCAM rs1157G>A, EpCAM rs1126497T>C emerged as best significant interaction model with GBC susceptibility and ALDH1A1 rs13959T>G with increased risk of grade 3-4 hematological toxicity.
|
26318430 |
2016 |
|
rs11954856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gene-gene interaction using GMDR analysis predicted APC rs11954856 and AXIN2 rs4791171 as significant in conferring GBC susceptibility.
|
26715268 |
2016 |