rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A combination of encorafenib, cetuximab, and binimetinib resulted in significantly longer overall survival and a higher response rate than standard therapy in patients with metastatic colorectal cancer with the <i>BRAF</i> V600E mutation.
|
31566309 |
2019 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Binimetinib, encorafenib and cetuximab (BEACON Trial) combination therapy for patients with BRAF V600E-mutant metastatic colorectal cancer.
|
31840683 |
2019 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis.
|
30662270 |
2019 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Promising clinical trials using combination therapies that inhibit the mitogen-activated protein kinase (MAPK) pathway and alternative active pathways have demonstrated major advances for patients with BRAF V600E-mutated mCRC.
|
31219603 |
2019 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Approximately 10% of metastatic colorectal cancer (mCRC) cases will harbor the BRAF p.V600E mutation (BRAF-mCRC) and have been associated with a poor prognosis.
|
30638691 |
2019 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehensive Cancer genomics (BREAC) study.
|
28972961 |
2017 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of 63 patients with BRAF V600E-mutated mCRC and sufficient clinical data, 27 (42.9%) had right-sided colon tumors, 19 (30.2%) had left-sided colon tumors, and 17 (26.9%) had rectal tumors; 26 (41.3%) had peritoneal metastases, and 50 (79.4%) had distant lymph node metastases.
|
29037218 |
2017 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Differential Radiographic Appearance of BRAF V600E-Mutant Metastatic Colorectal Cancer in Patients Matched by Primary Tumor Location.
|
27956538 |
2016 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E mutation in metastatic colorectal cancer: Methods of detection and correlation with clinical and pathologic features.
|
27261210 |
2016 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Metastatic colorectal cancer (mCRC) that harbours a BRAF V600E mutation (BRAF MT) is associated with poorer outcomes.
|
25989278 |
2015 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that combined therapy with RAF and EGFR inhibitors could be an effective strategy for treating BRAF V600E mCRC.
|
25589621 |
2015 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF codon 594 or 596 mutated mCRCs are different from BRAF V600E ones in terms of molecular features, pathological characteristics and clinical outcome.
|
26153495 |
2015 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E mutation is seen in 5% to 8% of patients with metastatic colorectal cancer (CRC) and is associated with poor prognosis.
|
26460303 |
2015 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Since RAC1b has been associated with the BRAF(V600E) mutation, associated with poor prognosis in CRC, we evaluated the role of RAC1b expression as a predictor of chemotherapy efficacy in mCRC.
|
24833563 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We describe survival outcomes and the impact of chemotherapy, metastatectomy, and BRAF V600E mutation status in the largest reported cohort of MSI-H metastatic colorectal cancer (CRC).
|
24585723 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By calculating the ΔC q for real-time traditional PCR, which amplifies all BRAF alleles, versus WTB-PCR, which selectively amplifies mutant BRAF, we demonstrated that among the V600E-positive mCRC patient samples, the percentage of BRAF DNA with the V600E mutation ranged from 0.05 to 52.32%.
|
24500755 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IHC using the VE1 clone is a specific and sensitive method for the detection of BRAF(V600E) and may be either a complementary or an alternative method to molecular testing in mCRC patients.
|
24798160 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here we report the first clinical evidence that the combination of an anti-EGFR (panitumumab) and an inhibitor of BRAF(V600E) (vemurafenib) is well tolerated and results in a strong disease control in an extensively pretreated mCRC patient.
|
24755613 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF V600E mutation plays a negative prognostic role in metastatic colorectal cancer (mCRC), leading to a median Progression Free Survival (PFS) of 4-6months with first-line conventional treatments.
|
24138831 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study aimed to evaluate the relationship between BRAF V600E mutation and the tumor response of anti-EGFR MoAbs for first-line treatment in mCRC patients.
|
24390240 |
2014 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Inadequate evidence was found regarding association of BRAF V600E mutation testing or loss of PTEN expression with improved health outcomes among patients with mCRC undergoing anti-EGFR therapy as compared with patients with tumors bearing wild-type BRAF sequence and PTEN expression levels, respectively.
|
23429431 |
2013 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we described the KRAS and the BRAF V600E mutation spectra and frequencies in a group of Serbian mCRC specimens.
|
23033302 |
2012 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BRAF p.Val600Glu (V600E) somatic mutation is mainly associated with MSS phenotype in metastatic colorectal cancer.
|
21289333 |
2011 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, 239 samples obtained from 215 patients with metastatic colorectal cancer were tested for the presence of the seven most common mutations in the KRAS gene and the V600E mutation in the BRAF gene.
|
20645028 |
2011 |
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis provides evidence that BRAF V600E mutation is associated with lack of response in wild-type KRAS mCRC treated with anti-EGFR MoAbs.
|
20857202 |
2011 |