|
rs121913322
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs121964872
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs80357522
|
|
CT |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs80357678
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs864622149
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs370681
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> Significantly increased EOC risk was found associated with the A/C heterozygous genotype of rs12921862, the C allele and C/T genotype in the rs1805105 and the T/T genotype of rs370681.
|
30929455 |
2019 |
|
rs851797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>EXO1</i> rs851797 polymorphism can predict the clinical outcomes in EOC patients.
|
29042795 |
2017 |
|
rs1695
|
|
|
0.060 |
GeneticVariation |
BEFREE |
<i>GSTP1</i> rs1695 is associated with both hematological toxicity and prognosis of ovarian cancer treated with paclitaxel plus carboplatin combination chemotherapy: a comprehensive analysis using targeted resequencing of 100 pharmacogenes.
|
30038720 |
2018 |
|
rs2070074
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The difference was most evident for endometrioid and clear cell types of ovarian cancer, in which 3.9% of cases were found to be homozygous for N314D compared with 0.4% of controls, yielding an odds ratio and 95% confidence interval of 14.17 (2.62-76.60).
|
10667469 |
2000 |
|
rs1048943
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Ile462Val status seems to represent a meaningful risk factor for ovarian cancer in Caucasians.
|
22733497 |
2012 |
|
rs1444192401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer.
|
28662703 |
2017 |
|
rs876660754
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer.
|
28662703 |
2017 |
|
rs904571820
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer.
|
28662703 |
2017 |
|
rs3814113
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A genome-wide association study recently identified an association between the rare allele of the single-nucleotide polymorphism (SNP) rs3814113 (ie, the C allele) at 9p22.2 and decreased risk of ovarian cancer for women in the general population.
|
21169536 |
2011 |
|
rs748876625
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A group of 63 families from the Pomerania-Kujawy region were analyzed for three BRCA1 gene Polish founder mutations, 5382insC, 300T>G, and 4153delA, because of breast (BrCa) and/or ovarian cancer (OvCa) history.
|
14986830 |
2003 |
|
rs7305032
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A larger sample of African Americans revealed a nearly two-fold increased risk of invasive EOC associated with rs7305032, a SNP in proximity to rs7975232 (R(2)=0.369) with a log-additive OR of 1.87 (95% CI=1.20, 2.93, p=0.006).
|
23262379 |
2013 |
|
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A patient with V600E BRAF-mutant melanoma and another with platinum-refractory epithelial ovarian cancer exhibiting PTEN loss and PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively.
|
25370471 |
2015 |
|
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A patient with V600E BRAF-mutant melanoma and another with platinum-refractory epithelial ovarian cancer exhibiting PTEN loss and PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively.
|
25370471 |
2015 |
|
rs10017134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10<sup>-6</sup> , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10<sup>-5</sup> , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10<sup>-5</sup> , BFDP = 0.23).
|
31001917 |
2019 |
|
rs114972508
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10<sup>-6</sup> , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10<sup>-5</sup> , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10<sup>-5</sup> , BFDP = 0.23).
|
31001917 |
2019 |
|
rs1017134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10<sup>-6</sup> , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10<sup>-5</sup> , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10<sup>-5</sup> , BFDP = 0.23).
|
31001917 |
2019 |
|
rs2066827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A slightly deceased risk of cancer was also indicated in Caucasians consisting of 6707 cases and 8279 controls (pooled OR 0.91, 95% CI: 0.85-0.98; model, TG vs. TT).These data suggest that carriage of a TG genotype at rs2066827 polymorphism may be associated with decreased susceptibility to cancer, ovarian cancer in particular.
|
26579796 |
2015 |
|
rs10069690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A splicing variant in TERT, rs10069690, showed a statistically significant interaction with ET use for risk of serous ovarian cancer (p<sub>int</sub> = 0.013).
|
27420401 |
2016 |
|
rs2229109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.
|
17828752 |
2008 |
|
rs17329882
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, haplotype analyses indicated that the haplotype block that contained rs17329882 was significantly associated with epithelial ovarian cancer risk, specifically with the serous epithelial ovarian cancer subtype.
|
28231729 |
2017 |