Using DNA isolated from blood taken from patients (<i>n</i> = 312) and a control group (<i>n</i> = 320) with CRC, we have analyzed the polymorphisms of selected DNA repair genes and we have demonstrated that genotypes 51Gln/His and 148Asp/Glu of APEX gene and 23Gly/Ala of XPA gene may increase the risk of colorectal cancer.