rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The conclusion is that the APC I1307K variant leads to increased adenoma formation and colorectal cancer.
|
17854661 |
2007 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The conclusion is that the APC I1307K variant leads to increased adenoma formation and colorectal cancer.
|
17854661 |
2007 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I1307K would be clinically useful.
|
16875934 |
2006 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we used this design to evaluate inherited susceptibility to prostate cancer associated with APC I1307K using data from the Molecular Epidemiology of Colorectal Cancer study.
|
16537703 |
2006 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We could find no group of Ashkenazi Jews with colorectal cancer for whom screening for I1307K would be clinically useful.
|
16875934 |
2006 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we used this design to evaluate inherited susceptibility to prostate cancer associated with APC I1307K using data from the Molecular Epidemiology of Colorectal Cancer study.
|
16537703 |
2006 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This excess can partially be attributed to inherited factors that are over represented in this population, such as the APC variant I1307K, which is associated with a modest increase in colorectal cancer risk.
|
16195945 |
2005 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
|
16228836 |
2005 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
|
15733272 |
2005 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Together with former evidence of I1307K being a risk factor for colorectal cancer, these data suggest that colonoscopic surveillance for colorectal adenomas and cancer may be warranted in I1307K carriers, even in the absence of other identifiable risk factors.
|
16228836 |
2005 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This excess can partially be attributed to inherited factors that are over represented in this population, such as the APC variant I1307K, which is associated with a modest increase in colorectal cancer risk.
|
16195945 |
2005 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While the I1307K APC mutation clearly confers an increased lifetime risk for colorectal cancer, there is a paucity of data on the natural history of colonic neoplasia in symptomatic and asymptomatic mutation carriers.
|
15733272 |
2005 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC polymorphism/mutation is carried by 6-8% of Ashkenazim and increases the risk of colorectal cancer 1.5-2 fold.
|
15516844 |
2004 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC polymorphism/mutation is carried by 6-8% of Ashkenazim and increases the risk of colorectal cancer 1.5-2 fold.
|
15516844 |
2004 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There is inconsistent evidence as to whether or not I1307K confers an increased risk of colorectal cancer.
|
12533824 |
2003 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There is inconsistent evidence as to whether or not I1307K confers an increased risk of colorectal cancer.
|
12533824 |
2003 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7).
|
11159880 |
2001 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our aim was to investigate the prevalence of I1307K and E1317Q in Swedish colorectal cancer patients in order to determine if these genetic variants are important predisposing factors to colorectal cancer in this population.
|
11267860 |
2001 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7).
|
11159880 |
2001 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our aim was to investigate the prevalence of I1307K and E1317Q in Swedish colorectal cancer patients in order to determine if these genetic variants are important predisposing factors to colorectal cancer in this population.
|
11267860 |
2001 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the carrier rate of the I1307K mutation in Ashkenazi Jewish patients with a history of colorectal polyps but without colorectal cancer and to compare phenotypic characteristics and family history of carriers vs noncarriers.
|
10938175 |
2000 |
rs1801155
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To determine the carrier rate of the I1307K mutation in Ashkenazi Jewish patients with a history of colorectal polyps but without colorectal cancer and to compare phenotypic characteristics and family history of carriers vs noncarriers.
|
10938175 |
2000 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An adenomatous polyposis coli (APC) gene variant (I1307K allele), which was recently reported in 1 in 17 Ashkenazi Jewish persons, may double the risk for colorectal cancer in that population.
|
10343885 |
1999 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the APC I1307K variant leads to increased adenoma formation and directly contributes to 3%-4% of all Ashkenazi Jewish colorectal cancer.
|
9973276 |
1999 |
rs1463038513
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The I1307K APC variant may represent a susceptibility gene for colorectal, or other, cancers in Ashkenazi Jews, and partially explains the higher incidence of colorectal cancer in European Israelis.
|
9869602 |
1999 |