Gene: MUTYH ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs34612342
rs34612342
MUTYH
0.050 GeneticVariation BEFREE Frequency of the common germline MUTYH mutations p.G396D and p.Y179C in patients diagnosed with colorectal cancer in Southern Brazil. 21424714

2011
dbSNP: rs34612342
rs34612342
MUTYH
0.050 GeneticVariation BEFREE Association tests demonstrated an increased odds ratio (OR) for CRC in carriers of the p.Tyr165Cys risk allele among fCRC patients, as compared to sporadic CRC patients and controls (OR 2.38; p=0.03). 18503156

2008
dbSNP: rs34612342
rs34612342
MUTYH
0.050 GeneticVariation BEFREE The two most common hMYH variants found in patients with colorectal cancer are Y165C and G382D. 15661655

2005
dbSNP: rs34612342
rs34612342
MUTYH
0.050 GeneticVariation BEFREE We used a population-based series of 1238 colorectal cancer patients and 1255 healthy control subjects from Ontario, Canada, to examine the risk of colorectal cancer among biallelic and monoallelic germline MYH Y165C and G382D mutation carriers. 15523092

2004
dbSNP: rs34612342
rs34612342
MUTYH
0.050 GeneticVariation BEFREE Here, we report the identification of seven further unrelated patients with >100 colorectal adenomas (six with colorectal cancer) and biallelic germline mutations in MYH: four were homozygous for truncating mutations, two were homozygous for Y165C and one was a Y165C/G382D compound heterozygote. 12393807

2002
dbSNP: rs36053993
rs36053993
MUTYH
0.030 GeneticVariation BEFREE Frequency of the common germline MUTYH mutations p.G396D and p.Y179C in patients diagnosed with colorectal cancer in Southern Brazil. 21424714

2011
dbSNP: rs36053993
rs36053993
MUTYH
0.030 GeneticVariation BEFREE The two most common hMYH variants found in patients with colorectal cancer are Y165C and G382D. 15661655

2005
dbSNP: rs36053993
rs36053993
MUTYH
0.030 GeneticVariation BEFREE We used a population-based series of 1238 colorectal cancer patients and 1255 healthy control subjects from Ontario, Canada, to examine the risk of colorectal cancer among biallelic and monoallelic germline MYH Y165C and G382D mutation carriers. 15523092

2004
dbSNP: rs587782041
rs587782041
MUTYH
0.010 GeneticVariation BEFREE Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer. 24799981

2014
dbSNP: rs765123255
rs765123255
MUTYH
0.010 GeneticVariation BEFREE Impaired 8-hydroxyguanine repair activity of MUTYH variant p.Arg109Trp found in a Japanese patient with early-onset colorectal cancer. 24799981

2014
dbSNP: rs3219489
rs3219489
MUTYH
0.010 GeneticVariation BEFREE The MUTYH Gln324His is strongly associated with colorectal cancer susceptibility in never smoking history, whereas the APEX1 Asp148Glu genotype constitutes an increased risk of colorectal cancer when accompanied by smoking exposure. 18823566

2008
dbSNP: rs369410616
rs369410616
MUTYH
0.010 GeneticVariation BEFREE However, the distributions of OGG1 Ser326Cys and XRCC1 Arg399Gln were not associated with a colorectal cancer risk. 18823566

2008
dbSNP: rs143353451
rs143353451
MUTYH
0.010 GeneticVariation BEFREE This result raises the possibility that OGG1 R154H may function as a low/moderate-penetrance modifier for colorectal cancer development. 15449173

2004