|
rs1799977
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The G allele of rs1799977 polymorphism was proved to connect with susceptibility of colorectal cancer (allele model: OR = 1.21, P = 0.023; dominate model: OR = 1.32, P <0.0001) and prostate cancer (dominate model: OR = 1.36, P <0.0001).
|
29190978 |
2017 |
|
rs35502531
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The MLH1 c.1852_1853delinsGC (p.K618A) variant in colorectal cancer: genetic association study in 18,723 individuals.
|
24743384 |
2014 |
|
rs876658657
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The MLH1 -93G>A (rs1800734) polymorphism was detected by PCR-RFLP in 49 cases of colorectal cancer.
|
25115745 |
2014 |
|
rs1799977
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The MLH1 I219V polymorphism was associated with colorectal cancer susceptibility (P=0.01).
|
24595079 |
2013 |
|
rs35502531
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We also reviewed the literature concerning MLH1 K618A in families with colorectal cancer.
|
22426235 |
2012 |
|
rs35502531
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We genotyped p.Lys618Ala in 1034 individuals (373 sporadic colorectal cancer [CRC] patients, 250 index subjects from families suspected of having LS [revised Bethesda guidelines] and 411 controls).
|
21247423 |
2011 |
|
rs56250509
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status.
|
18595133 |
2008 |
|
rs876658657
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The MLH1 -93 G>A promoter polymorphism has been reported to be associated with an increased risk of microsatellite unstable colorectal cancer.
|
18615680 |
2008 |
|
rs1799977
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Four single nucleotide polymorphisms in 3 mismatch repair genes (MSH3 R940Q, MSH3 T1036A, MSH6 G39E and MLH1 I219V) were genotyped in 237 colorectal cancer cases and a subcohort of 2,189 participants.
|
17205513 |
2007 |
|
rs56250509
|
|
|
0.030 |
GeneticVariation |
BEFREE |
MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.
|
17350979 |
2007 |
|
rs876658657
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Among case patients from Ontario, an association between the MLH1 -93G>A polymorphism and a strong family history of colorectal cancer (for Amsterdam criteria I and II, P = .004 and P = .02, respectively) was observed.
|
17374836 |
2007 |
|
rs56250509
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the mechanism responsible for the link between the C677T polymorphism and microsatellite instability was not apparent, this finding may provide a clue towards a better understanding of the pathogenesis of microsatellite instability in human colorectal cancer.
|
16819711 |
2006 |
|
rs1800734
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Modulation of transcription factor binding and epigenetic regulation of the MLH1 CpG island and shore by polymorphism rs1800734 in colorectal cancer.
|
28304185 |
2017 |
|
rs756045117
|
|
|
0.020 |
GeneticVariation |
BEFREE |
DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes.
|
25769449 |
2015 |
|
rs1800734
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The MLH1 -93G>A (rs1800734) polymorphism was detected by PCR-RFLP in 49 cases of colorectal cancer.
|
25115745 |
2014 |
|
rs1418586322
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously described a founder mutation, MSH2*1906G >C (A636P) that causes HNPCC in 8/1345 (0.59%) of Ashkenazim with colorectal cancer.
|
17414604 |
2007 |
|
rs756045117
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, we have found a strong association between the germline polymorphism (c.-56C>T) of the MGMT promoter and promoter methylation/silencing of MGMT in colorectal cancer.
|
17621591 |
2007 |
|
rs28930073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The MLH1 D132H risk variant has significantly lower allele frequency in American compared with Israeli cancer patients and, alone, is unlikely to explain significant amounts of American sporadic colorectal cancer or uterine cancer susceptibility.
|
15991064 |
2005 |
|
rs1418586322
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although rare in the general population, the A636P mutation is detected in up to 7% of Ashkenazi Jewish patients with early age-of-onset colorectal cancer, and may account for up to one third of HNPCC in the Ashkenazi Jewish population.
|
15516845 |
2004 |
|
rs28930073
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer.
|
15184898 |
2004 |
|
rs63751310
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R659X mutation in the MLH1 gene in hereditary non-polyposis colorectal cancer(HNPCC) in an Indian extended family.
|
20167975 |
2010 |
|
rs1466012753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we have found a strong association between the germline polymorphism (c.-56C>T) of the MGMT promoter and promoter methylation/silencing of MGMT in colorectal cancer.
|
17621591 |
2007 |
|
rs63750447
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a search for germline mutations in the DNA mismatch repair genes hMSH2 and hMLH1 in Chinese patients with colorectal cancer we identified a novel missense mutation (V384D) in exon 12 of the hMLH1 gene in 4 out of 26 individuals.
|
9526167 |
1998 |