|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Transcriptome profiling identified ADORA2B as up-regulated in basal-like TNBC cell lines with R248Q-mutated TP53, with shRNA-screening suggesting the potential for a synthetic-lethal interaction between these genes.
|
30349649 |
2018 |
|
rs11540652
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study supports using the biological markers of high expression of mtp53 R273H or R248Q as additional diagnostics for TNBC resistant subtypes often found in the AA community.
|
26703669 |
2015 |
|
rs2363956
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Additionally, rs4849887 was significantly associated with overall BC risk, and both rs2363956 and rs13000023 were associated with TNBC-specific risk, although none as strongly as the Duffy-null variant.
|
31356281 |
2019 |
|
rs2363956
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The five SNPs were also associated with triple-negative breast cancer in a separate study of 2,301 triple-negative cases and 3,949 controls (P(trend) = 1 × 10⁻⁷) to P(trend) = 8 × 10⁻⁵; rs2363956 per-allele OR = 0.80, 95% CI 0.74-0.87, P(trend) = 1.1 × 10⁻⁷
|
20852631 |
2010 |
|
rs4987188
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Structural debilitation of mutation G322D associated with MSH2 and their role in triple negative breast cancer.
|
30806579 |
2020 |
|
rs4987188
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The Gly322Asp polymorphism of the hMSH2 gene may be linked with TNBC occurrence in Polish women.
|
25134804 |
2015 |
|
rs8170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, a combined analysis of triple-negative cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC; N = 3,566) identified a genome-wide significant association between rs8170 and triple-negative breast cancer risk (OR, 1.25; 95% CI, 1.18-1.33; P = 3.31 × 10(-13)].
|
22331459 |
2012 |
|
rs8170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer.
|
21844186 |
2011 |
|
rs861539
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population.
|
24728564 |
2015 |
|
rs861539
|
|
|
0.020 |
GeneticVariation |
BEFREE |
XRCC3 rs861539 TT is a potential predictive marker for TNBC in Taiwanese women and investigations in other populations are warranted for further universal application in cancer detection and prediction.
|
26543082 |
2016 |
|
rs10274701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs10274701 significantly increased the EZH2 expression level in TNBC (p = 0.01).
|
26162541 |
2015 |
|
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, genetic variants in <i>TP53</i> were found in all TNBC tumors, with rs1042522 being the most frequent (94% of TNBC biopsies), which had not been previously reported in TNBC.
|
30867801 |
2019 |
|
rs1042821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TNBC was associated with 6 DNA-repair nsSNPs, ERCC4 R415Q (rs1800067), MSH3 R940Q (rs184967), MSH6 G39E (rs1042821), POLD1 R119H (rs1726801), XRCC1 R194W (rs1799782), and XPC A499V (rs2228000) and/or deficiencies in 3 micronutrients (zinc, folate, and β-carotene).
|
25023197 |
2014 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant associations between Ser326Cys and Arg194Trp genotype and TNBC were observed.
|
24402573 |
2014 |
|
rs1054135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical staining of adipocytes adjacent to TNBC tissues showed that the expression level of FABP4 was statistically significantly lower in patients with the rs1054135-GG genotype and those in the disease-free group (P=0.0004 and P=0.0091, respectively).
|
26959740 |
2016 |
|
rs1057519847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer.
|
25789532 |
2015 |
|
rs1057519848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer.
|
25789532 |
2015 |
|
rs1064793184
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TNBC was associated with 6 DNA-repair nsSNPs, ERCC4 R415Q (rs1800067), MSH3 R940Q (rs184967), MSH6 G39E (rs1042821), POLD1 R119H (rs1726801), XRCC1 R194W (rs1799782), and XPC A499V (rs2228000) and/or deficiencies in 3 micronutrients (zinc, folate, and β-carotene).
|
25023197 |
2014 |
|
rs1064793309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a result of a routine BRCA1/BRCA2 mutational screening, we identified a previously unreported BRCA1 sequence alteration [c.5178G>A (V1687I)] in a patient diagnosed with early onset triple negative breast cancer.
|
22527099 |
2012 |
|
rs1114167795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TNBC was associated with 6 DNA-repair nsSNPs, ERCC4 R415Q (rs1800067), MSH3 R940Q (rs184967), MSH6 G39E (rs1042821), POLD1 R119H (rs1726801), XRCC1 R194W (rs1799782), and XPC A499V (rs2228000) and/or deficiencies in 3 micronutrients (zinc, folate, and β-carotene).
|
25023197 |
2014 |
|
rs11615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings firstly show that the T allele of ERCC1 rs11615 can serve as a predictive biomarker for breast cancer and TNBC.
|
30096175 |
2018 |
|
rs12075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggested that rs12075 could be served as a key predictive factor of recurrence risk in breast cancer, especially for TNBC subtype.
|
30358125 |
2018 |
|
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer.
|
25789532 |
2015 |
|
rs121913016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Whole exome sequencing in triple negative breast cancer cases (n = 8) and targeted sequencing in healthy controls (n = 48) revealed BRIP1 rs552752779 (MAF: 75% vs. 6.25%, OR 45.00, 95% CI 9.43-243.32), ERBB2 rs527779103 (MAF: 62.5% vs. 7.29%, OR 21.19, 95% CI 5.11-94.32), ERCC2 rs121913016 (MAF: 56.25% vs. 7.29%, OR 16.34, 95% CI 4.02-70.41), MSH6 rs2020912 (MAF: 56.25% vs. 1.04%, OR 122.13, 95% CI 12.29-2985.48) as risk factors for triple negative breast cancer.
|
30136158 |
2018 |
|
rs1219648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratified by breast cancer subtype, all five SNPs were associated (P < 0.05) with ER+ cancer, three with ER- cancer (rs13387042, rs1219648, and rs4784227), and one with TNBC (rs1219648).
|
24510657 |
2015 |