Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11540652
rs11540652
0.020 GeneticVariation BEFREE This study supports using the biological markers of high expression of mtp53 R273H or R248Q as additional diagnostics for TNBC resistant subtypes often found in the AA community. 26703669

2015

dbSNP: rs28934576
rs28934576
0.010 GeneticVariation BEFREE This study supports using the biological markers of high expression of mtp53 R273H or R248Q as additional diagnostics for TNBC resistant subtypes often found in the AA community. 26703669

2015

dbSNP: rs11540652
rs11540652
0.020 GeneticVariation BEFREE Transcriptome profiling identified ADORA2B as up-regulated in basal-like TNBC cell lines with R248Q-mutated TP53, with shRNA-screening suggesting the potential for a synthetic-lethal interaction between these genes. 30349649

2018

dbSNP: rs1042522
rs1042522
0.010 GeneticVariation BEFREE In conclusion, genetic variants in <i>TP53</i> were found in all TNBC tumors, with rs1042522 being the most frequent (94% of TNBC biopsies), which had not been previously reported in TNBC. 30867801

2019