|
rs765433422
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three PDXs were selected for their lack of PTEN expression by immunohistochemistry: a triple-negative breast cancer (TNBC), a <i>KRAS</i> G12R low-grade serous ovarian cancer (LGSOC), and <i>KRAS</i> G12C and <i>TP53</i> R181P lung adenocarcinoma (LADC).
|
29156674 |
2017 |
|
rs799917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations between the rs799917 polymorphism and progression risk were investigated after genotyping 370 TNBC patients.
|
28744749 |
2017 |
|
rs80350973
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although its low prevalence had not indicated any particular clinical significance in previous studies, our results associated rs80350973 mutation with cell checkpoint malfunction, and was found to be more common in TNBC patients with high Ki-67 indices (P = 0.004).
|
28135048 |
2017 |
|
rs1054135
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical staining of adipocytes adjacent to TNBC tissues showed that the expression level of FABP4 was statistically significantly lower in patients with the rs1054135-GG genotype and those in the disease-free group (P=0.0004 and P=0.0091, respectively).
|
26959740 |
2016 |
|
rs2278256
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the haplotypes containing two polymorphisms rs7250266 and rs2278256 are associated with a lower chance of TNBC development specifically.
|
26848770 |
2016 |
|
rs587780021
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found four good candidate pathogenic BARD1 mutations in the TNBC cohort, including two protein-truncating mutations (p.Gln564Ter and p.Arg641Ter).
|
26010302 |
2016 |
|
rs587781948
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found four good candidate pathogenic BARD1 mutations in the TNBC cohort, including two protein-truncating mutations (p.Gln564Ter and p.Arg641Ter).
|
26010302 |
2016 |
|
rs7250266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs7250266 in the promoter region of NBA1 confers a decreased risk to TNBC development, but not to non-TNBC</span> susceptibility.
|
26848770 |
2016 |
|
rs80356898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found four good candidate pathogenic BARD1 mutations in the TNBC cohort, including two protein-truncating mutations (p.Gln564Ter and p.Arg641Ter).
|
26010302 |
2016 |
|
rs10274701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G allele of rs10274701 significantly increased the EZH2 expression level in TNBC (p = 0.01).
|
26162541 |
2015 |
|
rs1057519847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer.
|
25789532 |
2015 |
|
rs1057519848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer.
|
25789532 |
2015 |
|
rs121434568
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer.
|
25789532 |
2015 |
|
rs1219648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratified by breast cancer subtype, all five SNPs were associated (P < 0.05) with ER+ cancer, three with ER- cancer (rs13387042, rs1219648, and rs4784227), and one with TNBC (rs1219648).
|
24510657 |
2015 |
|
rs16999593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TC genotypes of rs2288349 and rs16999593 were higher in TNBC compared with the control group; the cancer risk increased to 5.27 and 4.13, respectively (p < 0.001).
|
26162541 |
2015 |
|
rs17217772
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk of TNBC in the carriers of the Gly322Gly-Asn127Ser combined genotype was increased (OR 3.71; 95 % CI 1.36-10.10).
|
25134804 |
2015 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regarding relative gene expression, we found significant mRNA subexpression between the combined genotypes C/T + T/T (rs1801133) and triple negative breast cancer (TNBC) (P = 0.034).
|
25801246 |
2015 |
|
rs2077197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we identified seven published polymorphism sites in the promoter region and in 3'UTR of PARP1 by sequencing. rs7527192 and rs2077197 genotypes were found to be significantly associated with the cPARP1 expression in TNBC patients (rs7527192 AA+GA versus GG, p=0.014; rs2077197 AA+GA versus GG, p=0.041).
|
26261599 |
2015 |
|
rs2288349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The TC genotypes of rs2288349 and rs16999593 were higher in TNBC compared with the control group; the cancer risk increased to 5.27 and 4.13, respectively (p < 0.001).
|
26162541 |
2015 |
|
rs28934576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study supports using the biological markers of high expression of mtp53 R273H or R248Q as additional diagnostics for TNBC resistant subtypes often found in the AA community.
|
26703669 |
2015 |
|
rs3218536
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population.
|
24728564 |
2015 |
|
rs4784227
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When stratified by breast cancer subtype, all five SNPs were associated (P < 0.05) with ER+ cancer, three with ER- cancer (rs13387042, rs1219648, and rs4784227), and one with TNBC (rs1219648).
|
24510657 |
2015 |
|
rs718282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphisms of the XRCC2 gene -41657C/T (rs718282) and of the RAD51 gene, -172G/T (rs1801321), were investigated by PCR-RFLP in 70 patients with triple-negative breast cancer and 70 age- and sex matched non-cancer controls.
|
25743260 |
2015 |
|
rs7527192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings were confirmed in an independent validation set of 88 TNBCs (rs7527192 GG versus GA+AA, p=0.030; rs2077197 GG versus GA+AA, p=0.030).
|
26261599 |
2015 |
|
rs1042821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TNBC was associated with 6 DNA-repair nsSNPs, ERCC4 R415Q (rs1800067), MSH3 R940Q (rs184967), MSH6 G39E (rs1042821), POLD1 R119H (rs1726801), XRCC1 R194W (rs1799782), and XPC A499V (rs2228000) and/or deficiencies in 3 micronutrients (zinc, folate, and β-carotene).
|
25023197 |
2014 |