Disease: Impaired cognition
Source: BEFREE ×
Variant Gene DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Num. diseases
rs1217691063
MTHFR
0.330 0.920 1 11796309 missense variant A/G snv 4.0E-06 7.0E-06 614
rs6265
BDNF ; BDNF-AS
0.436 0.760 11 27658369 missense variant C/T snv 0.19 0.15 264
rs4680
COMT ; MIR4761
0.442 0.920 22 19963748 missense variant G/A snv 0.46 0.44 249
rs759834365
BDNF-AS ; BDNF
0.448 0.760 11 27658456 missense variant C/T snv 1.2E-05 237
rs1799945
LOC108783645 ; HFE
0.452 0.760 6 26090951 missense variant C/G;T snv 0.11 0.10 201
rs1800629
TNF
0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14 169
rs1801133
MTHFR
0.472 0.880 1 11796321 missense variant G/A snv 0.31 0.27 169
rs1800795
IL6-AS1 ; IL6 ; STEAP1B
0.494 0.840 7 22727026 intron variant C/G snv 0.71 140
rs1805087
MTR
0.496 0.800 1 236885200 missense variant A/G snv 0.20 0.21 135
rs1801282
PPARG
0.500 0.840 3 12351626 missense variant C/G snv 0.11 8.9E-02 127
rs1805192
PPARG
0.510 0.840 3 12379739 missense variant C/G snv 117
rs1801131
MTHFR
0.535 0.840 1 11794419 missense variant T/G snv 0.29 0.26 92
rs9939609
FTO
0.559 0.720 16 53786615 intron variant T/A snv 0.41 80
rs1061170
CFH
0.561 0.720 1 196690107 missense variant C/T snv 0.68 0.64 69
rs9340799
ESR1
0.583 0.680 6 151842246 intron variant A/G snv 0.32 62
rs1800497
ANKK1
0.620 0.400 11 113400106 missense variant G/A snv 0.26 0.26 56
rs2236225
MTHFD1
0.614 0.640 14 64442127 missense variant G/A snv 0.44 0.38 51
rs53576
OXTR ; CAV3
0.641 0.320 3 8762685 intron variant A/G;T snv 42
rs6295
HTR1A
0.645 0.200 5 63962738 intron variant C/G snv 0.49 40
rs746682028
BDNF ; BDNF-AS
0.645 0.480 11 27658414 missense variant C/A;T snv 4.0E-06; 4.0E-06 36
rs16969968
CHRNA5
0.653 0.360 15 78590583 missense variant G/A snv 0.26 0.24 34
rs74315401
PRNP
0.683 0.320 20 4699525 missense variant C/T snv 32
rs165599
ARVCF ; COMT
0.677 0.280 22 19969258 3 prime UTR variant G/A snv 0.56 27
rs4818
COMT ; MIR4761
0.683 0.440 22 19963684 synonymous variant C/G;T snv 0.34 27
rs1006737
CACNA1C
0.695 0.120 12 2236129 intron variant G/A snv 0.36 25