Disease: Impaired cognition
Source: ALL
Variant Gene DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Num. diseases
rs6265
BDNF ; BDNF-AS
0.436 0.760 11 27658369 missense variant C/T snv 0.19 0.15 272
rs4680
COMT ; MIR4761
0.442 0.920 22 19963748 missense variant G/A snv 0.46 0.44 249
rs759834365
BDNF-AS ; BDNF
0.448 0.760 11 27658456 missense variant C/T snv 1.2E-05 237
rs1799945
LOC108783645 ; HFE
0.452 0.760 6 26090951 missense variant C/G;T snv 0.11 0.10 226
rs104893877
SNCA
0.614 0.360 4 89828149 missense variant C/T snv 59
rs63751273
MAPT
0.645 0.280 17 46010389 missense variant C/T snv 42
rs63750424
MAPT
0.677 0.240 17 46024061 missense variant C/T snv 1.6E-05 30
rs11136000
CLU
0.752 0.160 8 27607002 intron variant T/C snv 0.56 19
rs781049584
APP
0.724 0.280 21 26021917 missense variant T/G snv 8.2E-06 7.0E-06 18
rs3851179 0.752 0.280 11 86157598 downstream gene variant T/C snv 0.70 15
rs17125721
PSEN1
0.763 0.120 14 73206470 missense variant A/G snv 1.5E-02 1.5E-02 14
rs12273363
BDNF
0.807 0.120 11 27723312 intron variant T/C snv 0.16 11
rs572842823
APP
0.763 0.160 21 25897626 missense variant T/A;G snv 11
rs775129479
SPSB3 ; IGFALS
0.851 0.120 16 1791387 missense variant G/A;C;T snv 1.6E-05; 8.1E-06; 8.1E-06 6
rs781587642
TUBA4A ; STK16
0.851 0.120 2 219250557 missense variant G/A;C snv 2.0E-05 6
rs8074995
PRKCA
0.925 0.040 17 66796013 intron variant G/A snv 0.13 5