LRRK2, leucine rich repeat kinase 2, 120892

N. diseases: 231; N. variants: 74
Source: ALL
Disease Type Disease Class Semantic Type N. genes d N. SNPs d Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
CUI: C1846862
Disease: PARKINSON DISEASE 8 (disorder)
PARKINSON DISEASE 8 (disorder) 		disease Disease or Syndrome 1 33 0.930 None 1.000 57 33 2004 2019
CUI: C0220870
Disease: Lightheadedness
Lightheadedness 		phenotype Pathological Conditions, Signs and Symptoms Sign or Symptom 1 1 0.010 None 1.000 1 1 2018 2018
CUI: C2751012
Disease: PARKINSON DISEASE 16 (disorder)
PARKINSON DISEASE 16 (disorder) 		disease Nervous System Diseases Disease or Syndrome 1 0.010 None 1.000 1 2018 2018
CUI: C0270699
Disease: Neonatal maladjustment syndrome
Neonatal maladjustment syndrome 		disease Disease or Syndrome 2 0.010 None 1.000 1 2015 2015
CUI: C4049471
Disease: End stage Parkinson's disease
End stage Parkinson's disease 		disease Disease or Syndrome 3 0.010 None 1.000 1 2017 2017
CUI: C4531177
Disease: Sleep onset Insomnia
Sleep onset Insomnia 		phenotype Nervous System Diseases; Mental Disorders Sign or Symptom 4 6 0.010 None 1.000 1 2015 2015
CUI: C3494361
Disease: Prodromal Stage
Prodromal Stage 		phenotype Pathological Conditions, Signs and Symptoms Sign or Symptom 8 0.010 None 1.000 1 2015 2015
CUI: C4274355
Disease: Autosomal dominant late onset Parkinson disease
Autosomal dominant late onset Parkinson disease 		disease Nervous System Diseases Disease or Syndrome 9 5 0.070 None 1.000 7 3 2005 2017
CUI: C4531121
Disease: Monotonic speech
Monotonic speech 		phenotype Finding 9 0.100 None 0
CUI: C1836904
Disease: Spastic/hyperactive bladder
Spastic/hyperactive bladder 		phenotype Finding 10 0.100 None 0
CUI: C1847640
Disease: KUFOR-RAKEB SYNDROME
KUFOR-RAKEB SYNDROME 		disease Nervous System Diseases Disease or Syndrome 11 16 0.010 None 1.000 1 1 2015 2015
CUI: C1868596
Disease: Atypical Parkinson Disease
Atypical Parkinson Disease 		disease Nervous System Diseases Disease or Syndrome 11 0.010 None 1.000 1 2019 2019
CUI: C0278097
Disease: Abnormal male sexual function
Abnormal male sexual function 		disease Mental or Behavioral Dysfunction 12 0.100 None 0
CUI: C1112443
Disease: Male sexual dysfunction
Male sexual dysfunction 		disease Disease or Syndrome 12 0.100 None 0
CUI: C0548883
Disease: Low frustration tolerance
Low frustration tolerance 		phenotype Behavior and Behavior Mechanisms Mental or Behavioral Dysfunction 14 0.100 None 0
CUI: C1846865
Disease: Substantia nigra gliosis
Substantia nigra gliosis 		phenotype Pathological Conditions, Signs and Symptoms Finding 14 0.100 None 0
CUI: C0027849
Disease: Neuroleptic Malignant Syndrome
Neuroleptic Malignant Syndrome 		disease Nervous System Diseases; Chemically-Induced Disorders Disease or Syndrome 16 4 0.010 None 1.000 1 2015 2015
CUI: C0679407
Disease: Gastrointestinal dysfunction
Gastrointestinal dysfunction 		phenotype Digestive System Diseases Disease or Syndrome 16 6 0.010 None 1.000 1 2014 2014
CUI: C1335723
Disease: Refractory Follicular Lymphoma
Refractory Follicular Lymphoma 		disease Neoplasms; Immune System Diseases; Hemic and Lymphatic Diseases Neoplastic Process 16 0.010 None 1.000 1 2019 2019
CUI: C1868528
Disease: Orthostatic hypotension due to autonomic dysfunction
Orthostatic hypotension due to autonomic dysfunction 		phenotype Nervous System Diseases; Cardiovascular Diseases Finding 16 0.100 None 0
CUI: C0030569
Disease: Secondary Parkinson Disease
Secondary Parkinson Disease 		disease Nervous System Diseases Disease or Syndrome 18 1 0.010 None 1.000 1 2019 2019
CUI: C0393571
Disease: Multiple System Atrophy
Multiple System Atrophy 		phenotype Nervous System Diseases Pathologic Function 19 6 0.030 None 1.000 3 2005 2008
CUI: C3825201
Disease: Mitochondrial pathology
Mitochondrial pathology 		phenotype Disease or Syndrome 20 6 0.010 None 1.000 1 2012 2012
CUI: C0338455
Disease: Dementia of frontal lobe type
Dementia of frontal lobe type 		disease Nervous System Diseases; Mental Disorders Disease or Syndrome 20 0.100 None 0
CUI: C1846868
Disease: Parkinsonism with favorable response to dopaminergic medication
Parkinsonism with favorable response to dopaminergic medication 		phenotype Nervous System Diseases Finding 21 2 0.100 None 0