NAT2, N-acetyltransferase 2, 10

N. diseases: 228; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE These results suggest that NAT2 polymorphisms do not exert a strong effect on individual susceptibility to MM. 18838334 2009
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Combination of NAT2 fast acetylator and GSTM1 null genotype posed a significantly increased risk of MM in the Italian, but not in the Finnish study. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 Biomarker disease CTD_human Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma.Cancer Res.55, 2981-2983; Hirvonen et al., 1996. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 Biomarker disease CTD_human The NAT2 fast acetylator and EPHX1 low-activity genotypes were positively associated with MM in the Italian study, while they were negatively associated with this malignancy in the Finnish one. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 Biomarker disease CTD_human Combination of NAT2 fast acetylator and GSTM1 null genotype posed a significantly increased risk of MM in the Italian, but not in the Finnish study. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 Biomarker disease CTD_human The role of CYP1A1, GSTM1, GSTT1, EPHX1, and NAT2 genotypes in susceptibility to malignant mesothelioma (MM) was compared in two case-control studies, previously conducted in two countries where different types of asbestos fibers have been used [Hirvonen et al., 1995. 16697254 2006
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Individuals who lacked the GSTM1 gene and possessed a NAT2 slow-acetylator genotype had a risk of developing malignant and nonmalignant pulmonary disorders that was approximately fivefold greater than that observed for those who had the GSTM1 gene and a NAT2 fast-acetylator genotype (OR = 5.1; 95% CI = 1.6-17.6); these individuals had a fourfold increased risk of developing nonmalignant pulmonary disorders (OR = 4.1; 95% CI = 1.1-17.2) and an eightfold increased risk of developing malignant mesothelioma (OR = 7.8; 95% CI = 1.4-78.7) when compared with the same reference group. 8961976 1997
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma
0.340 GeneticVariation disease BEFREE Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. 7606714 1995