|
Extraskeletal Myxoid Chondrosarcoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The EWS/TEC fusion protein encoded by the t(9:22) chromosomal translocation in human extraskeletal myxoid chondrosarcoma tumors is thought to participate in the tumoral process at least in part by deregulating the expression of specific target genes involved in the control of cell proliferation.
|
12049818 |
2002 |
|
Extraskeletal Myxoid Chondrosarcoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Extraskeletal myxoid chondrosarcoma (EMC) is characterized by recurrent chromosomal translocations resulting in fusions of the nuclear receptor gene NOR1 (also known as CHN or TEC) to various N-terminal partners, including EWS and TAF2N (or RBP56).
|
15188455 |
2004 |
|
Extraskeletal Myxoid Chondrosarcoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21).
|
11156374 |
2000 |
|
Extraskeletal Myxoid Chondrosarcoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Most, although not all, examples of EMC possess a unique balanced chromosomal translocation [t(9;22)(q22;q12)] between the EWSR1 and NR4A3 (previously termed TEC) genes.
|
22804337 |
2012 |
|
Chondrosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator.
|
10359536 |
1999 |
|
Adult Extraskeletal Myxoid Chondrosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21).
|
11156374 |
2000 |
|
Adult Extraskeletal Myxoid Chondrosarcoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The EWS/TEC fusion protein encoded by the t(9:22) chromosomal translocation in human extraskeletal myxoid chondrosarcoma tumors is thought to participate in the tumoral process at least in part by deregulating the expression of specific target genes involved in the control of cell proliferation.
|
12049818 |
2002 |
|
Hepatitis
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The liver inflammation in Traf6ΔTEC mice exhibited all the histological and immunological characteristics of human autoimmune hepatitis (AIH).
|
23867620 |
2013 |
|
Soft Tissue Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12)(FLI1;EWS), t(21;22)(q22;q12)(ERG; EWS); t(7;22)(p22;q12)(ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12)(WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12)(FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14)(PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11)(CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11)(SSX1&2;SYT), and others.
|
9344317 |
1997 |
|
Gastrointestinal Stromal Tumors
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Combined assessment of ctDNA with TEC-seq and ddPCR detected plasma mutations in 11 of 12 patients (92%). ctDNA studies showed that KIT secondary mutations remain the main mechanism of resistance in TKI-refractory GIST, revealing effective suppression of KIT-mutant subpopulations in patients benefiting from the combination.
|
31471313 |
2019 |
|
Desmoplastic Small Round Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12)(FLI1;EWS), t(21;22)(q22;q12)(ERG; EWS); t(7;22)(p22;q12)(ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12)(WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12)(FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14)(PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11)(CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11)(SSX1&2;SYT), and others.
|
9344317 |
1997 |
|
Adult Desmoplastic Small Round Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12)(FLI1;EWS), t(21;22)(q22;q12)(ERG; EWS); t(7;22)(p22;q12)(ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12)(WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12)(FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14)(PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11)(CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11)(SSX1&2;SYT), and others.
|
9344317 |
1997 |
|
Childhood Desmoplastic Small Round Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The potentially diagnostic chromosomal translocations and associated genes identified in STT include Ewing's/PNET t(11;22)(q24;q12)(FLI1;EWS), t(21;22)(q22;q12)(ERG; EWS); t(7;22)(p22;q12)(ETV1;EWS); desmoplastic small round cell tumor t(11;22)(p13;q12)(WT1;EWS); extraskeletal myxoid chondrosarcoma t(9;22)(q22;q12) (TEC(CHN);EWS); malignant ectomesenchymoma t(11;22)(q24;q12)(FLI1;EWS); alveolar rhabdomyosarcoma t(2;13)(q35;q14)(PAX-3;FKHR); t(1;13) (p36;q14)(PAX-7;FKHR); myxoid and round cell liposarcoma t(12;16)(q13;p11)(CHOP;TLS(FUS)); synovial sarcoma t(X;18)(p11;q11)(SSX1&2;SYT), and others.
|
9344317 |
1997 |
|
Liver carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Northern analysis further shows that in 2 out of 4 cell lines of human hepatocellular carcinoma (HCC) the tec gene is highly expressed compared to normal human liver.
|
2284097 |
1990 |
|
Childhood Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, high expression of the tec gene could be detected in all of the three patients examined with myelodysplastic syndrome.
|
7934162 |
1994 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Interestingly, high expression of the tec gene could be detected in all of the three patients examined with myelodysplastic syndrome.
|
7934162 |
1994 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, high expression of the tec gene could be detected in all of the three patients examined with myelodysplastic syndrome.
|
7934162 |
1994 |
|
Extraskeletal Myxoid Chondrosarcoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
|
10537274 |
1999 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data demonstrated that ECM-associated genes play pivotal roles in breast cancer EC biology and some of them could serve as potential TEC biomarkers for various cancers.
|
29541388 |
2018 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Fifty-nine Taiwanese women (mean age, 46 y; range, 30-64 y) treated for breast cancer with TEC were recruited.
|
19332043 |
2009 |
|
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our study support the view that BC cases under the TEC chemotherapy were related to higher overall response rates; and the chemotherapy with the TEC regimen could be served as an effective therapy in the treatment of BC.
|
25480315 |
2015 |
|
Chondrosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results suggest that EWS/TEC interacts at least in part with the same transcriptional coactivators as the native TEC receptor, and that these coactivators may be involved in the tumoral process leading to human chondrosarcoma tumors.
|
12049818 |
2002 |
|
Chondrosarcoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Because the NTDs of TFG-TEC and TEC are structurally different, and the TFG itself is a cytoplasmic protein, the functional consequences of this fusion in extraskeletal myxoid chondrosarcomas were examined.
|
22581839 |
2012 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
The bioengineered model recapitulated vasculogenic mimicry (vessel-like structure formation and tumor-derived endothelial cells-TECs), and contained CSLC expressing SOX2 and NANOG.
|
29158813 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
These results suggest that EWS/TEC interacts at least in part with the same transcriptional coactivators as the native TEC receptor, and that these coactivators may be involved in the tumoral process leading to human chondrosarcoma tumors.
|
12049818 |
2002 |