HDAC5, histone deacetylase 5, 10014

N. diseases: 114; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.500 Biomarker disease PSYGENET Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.500 Biomarker disease RGD Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.500 Biomarker disease PSYGENET Furthermore, viral-mediated HDAC5 overexpression in the hippocampus blocked imipramine's ability to reverse depression-like behavior. 16501568 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.400 GeneticVariation disease GWASCAT Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.320 Biomarker disease BEFREE We previously identified CYR61 as a histone deacetylase 5 (HDAC-5)-repressed gene in systemic sclerosis (SSc; scleroderma) endothelial cells (ECs). 30884213 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 AlteredExpression disease BEFREE Recently, we could distinguished patients with major depressive disorder (MDD) from nonpsychiatric controls with high accuracy using a panel of five gene expression markers (<i>ARHGAP24, HDAC5, PDGFC, PRNP</i>, and <i>SLC6A4</i>) in leukocyte. 28260899 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.320 Biomarker disease BEFREE Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. 27482699 2016
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma
0.320 Biomarker disease CTD_human Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. 27482699 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 Biomarker disease PSYGENET Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.320 AlteredExpression disease BEFREE Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 AlteredExpression disease BEFREE A gene network approach showed that the EHMT1, EHMT2, MAPK1, MAPK3, MAP2K1, and HDAC5 genes, which are involved in transcription and chromatin regulation cellular signaling pathways, were also associated with cocaine dependence. 31116258 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker disease PSYGENET Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 AlteredExpression disease BEFREE Our results suggest the alteration of HDAC5 and CREB gene expression in the systemic pathophysiology of major depression. 17258370 2007
CUI: C0600427
Disease: Cocaine Dependence
Cocaine Dependence
0.310 Therapeutic disease CTD_human Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. 17988634 2007
CUI: C0005587
Disease: Depression, Bipolar
Depression, Bipolar
0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
CUI: C0024713
Disease: Manic Disorder
Manic Disorder
0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
CUI: C0338831
Disease: Manic
Manic
0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.300 Biomarker disease GENOMICS_ENGLAND MicroRNA variants as genetic determinants of bone mass. 26723575 2016
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.300 Biomarker disease PSYGENET Administration of sodium valproate (VPA), a histone deacetylase 5 (HDAC5) inhibitor, not only significantly relieved the anxiety- and depression-like behaviors of CUS-induced rats but also clearly blunted decrease of H3(K9) and H4(K12) acetylation and expression of TH and TPH, and prevented increase of HDAC5 expression. 24495952 2014
Familial primary pulmonary hypertension
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
Pulmonary Hypertension, Primary, Fenfluramine-Associated
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012
Idiopathic pulmonary arterial hypertension
0.300 Biomarker disease CTD_human HDAC1 and HDAC5 protein levels were elevated in lungs from human idiopathic pulmonary arterial hypertension and in lungs and right ventricles from rats exposed to hypoxia. 22711276 2012
Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia
0.300 Biomarker disease CTD_human Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. 22711276 2012