BCL2L11, BCL2 like 11, 10018

N. diseases: 173; N. variants: 16
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE The increased apoptotic rates caused by the combination treatment were significantly reduced through siRNA knockdown of ATF4 and BIM, confirming its critical roles in this process.<b>Conclusions:</b> The data presented herein encourage further advanced <i>in vivo</i> and clinical studies to evaluate MEKi in combination with ER stress inducing BRAFi as a strategy to treat rapidly progressing NRAS-mutant melanoma.<i></i>. 28724666 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease LHGDN Active N-Ras and B-Raf inhibit anoikis by downregulating Bim expression in melanocytic cells. 18668139 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease LHGDN Together, our data show that Bad and Bim are major B-RAF responsive proteins regulating apoptosis in melanoma cells. 18246127 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease LHGDN Bim expression is reduced in human cutaneous melanomas. 17637819 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease BEFREE Interestingly, endogenous expression of BIM in melanoma cells was insufficient to induce apoptosis unless combined with serum deprivation. 18715233 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease LHGDN Interestingly, endogenous expression of BIM in melanoma cells was insufficient to induce apoptosis unless combined with serum deprivation. 18715233 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease LHGDN Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells. 17051334 2006