|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
A further study verified that the overexpression of LNK effectively reduced the invasion ability of the tumor cells in the transwell assay.
|
31706103 |
2020 |
|
Camurati-Engelmann Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Reverse modulation of gene-expression and methylation in the same cellular compartment was observed for the IL21 and SH2B3 genes in CeD patients relative to CTRs.
|
31292504 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study reveals an unappreciated function of LNK in melanoma and highlights the critical role of the IFN-STAT1-LNK signaling axis in this potentially devastating disease.
|
31110180 |
2019 |
|
Cutaneous Melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway.
|
31110180 |
2019 |
|
Peripheral Arterial Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
After Bonferroni correction, we found common variants in SH2B3, ABO, and ZEB2 to be associated with PAD ( P<4.5×10<sup>-5</sup>).
|
31070467 |
2019 |
|
Fanconi Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, deletion of LNK in human FA-like HSCs promotes clonogenic growth.
|
30254368 |
2018 |
|
Lymphoid leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia.
|
30005852 |
2018 |
|
acute aortic dissection
|
0.010 |
Biomarker
|
disease |
BEFREE |
LNK deficiency promotes acute aortic dissection and rupture.
|
30333305 |
2018 |
|
Dissection of aorta
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we identified a role for LNK in the pathology of AD in experimental animals and humans and describe a new model that can be used to inform both inherited and acquired forms of this disease.
|
30333305 |
2018 |
|
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, deletion of LNK in human FA-like HSCs promotes clonogenic growth.
|
30254368 |
2018 |
|
Hematological Disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In this context, the LNK inhibitory adaptor protein encoded by the LNK/SH2B adaptor protein 3 (SH2B3) gene is the target of several genetic variations, acquired or inherited in MPNs, lymphoid leukemia and nonmalignant hematological diseases, underlying its importance in these pathological processes.
|
28484264 |
2017 |
|
Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To understand the functional effects of LNK single-nucleotide polymorphisms and explore the mechanisms whereby LNK loss of function impacts atherosclerosis and thrombosis.
|
27430239 |
2016 |
|
Atherosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To understand the functional effects of LNK single-nucleotide polymorphisms and explore the mechanisms whereby LNK loss of function impacts atherosclerosis and thrombosis.
|
27430239 |
2016 |
|
Dengue Fever
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To examine the possible association of these SNPs with DHF, 918 Thai patients with dengue [509 patients with DHF and 409 with dengue fever (DF)] were genotyped for five SNPs: rs5745568 in BAK1, rs6141 in THPO, rs6065 in GP1BA, rs739496 in SH2B3, and rs385893 in RCL1.
|
27401010 |
2016 |
|
Hypercholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypercholesterolemia acts synergistically with LNK deficiency to increase interleukin 3/granulocyte-macrophage colony-stimulating factor receptor signaling in bone marrow myeloid progenitors, whereas in platelets cholesterol loading combines with Lnk deficiency to increase activation.
|
27430239 |
2016 |
|
Vascular inflammations
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Genetic animal models with deletion or mutation of LNK revealed an important role for LNK in renal and vascular inflammation, glomerular injury, oxidative stress, interferon-γ production, and hypertension.
|
26717315 |
2016 |
|
Precursor B-cell lymphoblastic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we demonstrated that LNK regulates pro-B progenitor homeostasis by attenuating IL-7-stimuated JAK/STAT5 signaling via a direct interaction with phosphorylated JAK3.
|
26974155 |
2016 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease).
|
26677855 |
2015 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic variations in inflammation and its related subpathway components are keys to the development of lung, colorectal, ovary, and breast cancer, including SH2B3, which is associated with lung, colorectal, and breast cancer.
|
26319099 |
2015 |
|
Malignant neoplasm of endometrium
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1.
|
26621817 |
2015 |
|
Graves Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This is the first study showing an association of the ATXN2/SH2B3 locus with susceptibility to GD.
|
25345847 |
2015 |
|
nervous system disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease).
|
26677855 |
2015 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
LNK (SH2B3): paradoxical effects in ovarian cancer.
|
24704825 |
2015 |
|
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified three pleiotropic loci within the inflammation pathway, including one novel locus in Ch12q24 encoding SH2B3 (rs3184504), which reached GWAS significance with a P value of 1.78 x 10(-8), and it showed an association with lung cancer (P = 2.01 x 10(-6)), colorectal cancer (GECCO P = 6.72x10(-6); CORECT P = 3.32x10(-5)), and breast cancer (P = .009).
|
26319099 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
LNK (SH2B3): paradoxical effects in ovarian cancer.
|
24704825 |
2015 |