Pallister-Killian syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Since many of computer-predicted miR-1244 target genes play roles in transcriptional regulation, overexpression of miR-1244 due to tetrasomy 12p may contribute to the pleiotropic phenotype of Pallister-Killian syndrome by modulating its downstream target genes including MEIS2 and UQCRB.
|
24981202 |
2014 |
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) formerly shown to be upregulated in urothelial bladder cancer were studied in corresponding normal and cancerous tissue samples of patients undergoing nephroureterectomy for UUTUC.
|
25629698 |
2015 |
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) formerly shown to be upregulated in urothelial bladder cancer were studied in corresponding normal and cancerous tissue samples of patients undergoing nephroureterectomy for UUTUC.
|
25629698 |
2015 |
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) formerly shown to be upregulated in urothelial bladder cancer were studied in corresponding normal and cancerous tissue samples of patients undergoing nephroureterectomy for UUTUC.
|
25629698 |
2015 |
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggested that there is an autoregulatory circuit consisting of miR-1244 and MEF2D, which contributes to the progression of lung cancer.
|
26355845 |
2015 |
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggested that there is an autoregulatory circuit consisting of miR-1244 and MEF2D, which contributes to the progression of lung cancer.
|
26355845 |
2015 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggested that there is an autoregulatory circuit consisting of miR-1244 and MEF2D, which contributes to the progression of lung cancer.
|
26355845 |
2015 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To explore the molecular mechanism by which lung cancer progresses, we employed multidisciplinary approaches and used lung cancer cell lines as research models. miR-1244 was underexpressed in lung carcinoma by 40.6-73.8%, which is highly associated with patients' survival. miR-1244 restoration was shown to affect the proliferation, survival, and invasion of lung cancer cells. miR-1244 suppression rendered normal lung fibroblasts with malignant phenotypes. miR-1244 overexpression can reduce the growth of lung cancer xenografts. miR-1244 was then verified to negatively regulate the expression of myocyte enhancer factor 2D (MEF2D) in lung cancer cells.
|
26355845 |
2015 |
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results of quantitative PCR analysis revealed that the expression levels of miR-1244 in cisplatin‑treated A549 and NCI-H522 human lung cancer cell lines were lower than those in untreated A549 and NCI-H522 cells.
|
28498474 |
2017 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results of quantitative PCR analysis revealed that the expression levels of miR-1244 in cisplatin‑treated A549 and NCI-H522 human lung cancer cell lines were lower than those in untreated A549 and NCI-H522 cells.
|
28498474 |
2017 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The results of quantitative PCR analysis revealed that the expression levels of miR-1244 in cisplatin‑treated A549 and NCI-H522 human lung cancer cell lines were lower than those in untreated A549 and NCI-H522 cells.
|
28498474 |
2017 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In summary, we found that miR-1244 affected cisplatin-treated NSCLC via MEF2D expression.
|
28498474 |
2017 |
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study shows that LINC00504 promotes OC cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment.
|
31691157 |
2020 |
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study shows that LINC00504 promotes OC cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment.
|
31691157 |
2020 |
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study shows that LINC00504 promotes OC cell progression and stimulates aerobic glycolysis by interacting with miR-1244, which indicates that LINC00504 might act as a promising therapeutic target for OC treatment.
|
31691157 |
2020 |