|
Acoustic Neuroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aggressive vestibular schwannomas showing postoperative rapid growth - their association with decreased p27 expression.
|
16283443 |
2005 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Whereas most of the investigated proteins were not differentially expressed, the cell-cycle inhibitor p27 was significantly reduced in USP8 mutated corticotroph adenoma (H-score 2.0 ± 1.0 vs 1.1 ± 1.1 in WT adenomas; P = 0.004).
|
30844069 |
2019 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The amount of p27 protein in corticotroph adenomas and pituitary carcinomas was much lower than that in normal pituitary tissue or other types of pituitary adenoma.
|
12050228 |
2002 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Intracellular SIV p27 was studied by flow cytometry in serial blood samples and lymph node samples during acute infection of 17 SIVmac-infected pigtail macaques.
|
22507218 |
2012 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
At diagnosis, p21 methylation was not detected in any case of AML or ALL. p27 methylation occurred in 2 (4%) AML patients and in 1 (4%) ALL patient. p57 methylation occurred in 1 (2%) AML patient and in 1 (4%) ALL patient.
|
16315255 |
2005 |
|
Acute onset pain
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study).
|
30782886 |
2019 |
|
Acute onset pain
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
A tramadol hydrochloride 75 mg/dexketoprofen 25 mg oral fixed combination (TRAM/DKP 75 mg/25 mg) has been recently registered and released in Europe for the treatment of moderate-to-severe acute pain.
|
28799579 |
2017 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Adenocarcinomas (AdCs) exhibited higher p27 levels compared to squamous cell carcinomas (SqCCs) (p < 0.01).
|
11474135 |
2001 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
We found reduced levels of p27 in 86% of cases and showed a statistically significant inverse correlation between p27 levels and tumor grade. ras mutations were found exclusively in adenocarcinomas and showed no relationship to p27 levels.
|
9973218 |
1999 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analysis revealed frequent loss of p27 expression in primary ovarian adenocarcinomas (33%), with respect to LMP tumors (6%; P = 0.0009).
|
10446997 |
1999 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
There was a significant difference in p27 expression between adenocarcinomas and normal mucosa (P<0.001, chi(2) = 13.333), which was related to the differentiation degree of adenoca rcinoma and lymph node metastasis (P<0.05, chi(2) = 8.901 chi(2) = 4).
|
15457580 |
2004 |
|
Adenocarcinoma
|
0.090 |
Biomarker
|
group |
BEFREE |
Because we had previously demonstrated that loss of p27 protein is associated with aggressive behavior in colorectal adenocarcinomas, we used immunohistochemistry and in situ hybridization to evaluate the potential role of alterations in p27 expression in primary and metastatic colorectal adenocarcinomas.
|
9736017 |
1998 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that JAB1 overexpression is involved in the pathogenesis of pancreatic cancer through JAB1-mediated p27 degradation and that control of JAB1 expression is a novel therapeutic target in patients with pancreatic adenocarcinomas.
|
16951171 |
2006 |
|
Adenocarcinoma
|
0.090 |
Biomarker
|
group |
BEFREE |
In contrast, absent or low p16, p21, and p27 immunostaining was observed in most HPV-negative cervical adenocarcinomas and might contribute to carcinogenesis in these tumors.
|
11499840 |
2001 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
An inverse relationship between p27 and Skp2 levels was found in adenocarcinomas and between p27 and Cks1 levels in squamous cell carcinomas.
|
19691991 |
2010 |
|
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Several novel findings were obtained: (i) cytoplasmic p27 was observed in 8.6%, most frequently in SCC (13.3%), and correlated with nodal metastasis (P=.0044), (ii) significant inverse correlation between nuclear p27 and Pirh2 expression was observed by statistical analysis and at the cellular level, and (iii) cytoplasmic Pirh2 and total (cytoplasmic and/or nuclear) Pirh2 were significantly correlated with the nodal status (P=.0225, 0.0314), the pathological stage (P=.0213, 0.0475) and recurrence-free survival (P=.0194, 0.0482, respectively) in AC.
|
28601655 |
2017 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Flavokawain C inhibited the growth of HT-29 human colon adenocarcinoma cellsFlavokawain C induced apoptosis in HT-29 cells, associated with an increase in reactive oxygen species and a decrease in SOD activityFlavokawain C induced cell cycle arrest at the G<sub>1</sub> and G<sub>2</sub>/M phases via upregulation of p21 and p27 in HT-29 cellsHT-29 cells treated with flavokawain C caused downregulation of XIAP, c-IAP1, and c-IAP2, and upregulation of GADD153.
|
28808400 |
2017 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression profile and cellular localizations of mucin proteins, CK7, and cytoplasmic p27 in Barrett's esophagus and esophageal adenocarcinoma.
|
29803118 |
2018 |
|
Adenocarcinoma of large intestine
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study adhered to MOOSE guidelines.Databases were searched for studies comparing KRAS, BRAF, microsatellite instability (MSI), CpG island methylator phenotype (CIMP), p53 and p27 status between patients with mucinous and non-mucinous colorectal adenocarcinoma.
|
30945755 |
2019 |
|
Adenocarcinoma of large intestine
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.
|
9736017 |
1998 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The negative correlation between LUADT1 and p27 expression was confirmed in LUAD tissue samples.
|
26291312 |
2015 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Starting from the observation that the growth-inhibitory and proapoptotic effects of miR-340 correlate with the accumulation of p27 in lung adenocarcinoma and glioblastoma cells, we have analyzed the functional relationship between miR-340 and p27 expression. miR-340 targets three key negative regulators of p27.
|
25151966 |
2015 |
|
Adenocarcinoma of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of p27 has been associated with poor prognosis in most human cancers, including pancreatic adenocarcinoma.
|
16951171 |
2006 |
|
Adenocarcinoma of pancreas
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, cyclin D1 overexpression and possibly p16 loss of expression in pancreatic adenocarcinoma seem to be adverse prognostic factors, whereas p27 expression did not seem to possess such prognostic properties.
|
25053516 |
2014 |
|
Adenocarcinoma, Endometrioid
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, survivin seems to exert its role in ways different from those of PTEN or p27 in the development of endometrioid adenocarcinoma.
|
16803539 |
2007 |