|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
The gp41 transmembrane domain (TMD) of the envelope glycoprotein of the human immunodeficiency virus modulates the conformation of the viral envelope spike, the only druggable target on the surface of the virion.
|
29972814 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, the hydrophobic patch is an evolutionarily conserved element in the tip of the gp120 V3 loop that plays an essential role in maintaining the stability of the pre-triggered Env trimer in diverse primate immunodeficiency viruses.
|
29936340 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
To expand the available array of multispecific HIV inhibitors, we designed single-component molecules that incorporate two (bispecific) or three (trispecific) bNAb binding sites that recognize the HIV envelope glycoprotein (Env) or the HIV coreceptor (CCR5) or that cross-target both Env and CCR5.
|
29976677 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Palmitoylation of the feline immunodeficiency virus envelope glycoprotein and its effect on fusion activity and envelope incorporation into virions.
|
22503389 |
2012 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Feline tetherin is characterized by a short N-terminal region and is counteracted by the feline immunodeficiency virus envelope glycoprotein.
|
22514338 |
2012 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
We studied the characteristics of HIV type 1 (HIV-1) in a 5-year old perinatally infected child with thymitis and compared the genomic sequences of the HIV-1 C2-V5 region of the env gene in the thymic tissue and peripheral blood.
|
20100091 |
2010 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Mutations at the C-terminus of the simian immunodeficiency virus envelope glycoprotein affect gp120-gp41 stability on virions.
|
16380144 |
2006 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
This CCR5-intrabody efficiently blocked surface expression of human and rhesus CCR5 and thus prevented cellular interactions with CCR5-dependent HIV-1 and simian immunodeficiency virus envelope glycoprotein.
|
10639161 |
2000 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To circumvent this problem, we pseudotyped MLV capsid particles with variants of Env proteins derived from the apathogenic simian immunodeficiency virus (SIVagm) of African green monkeys (AGM; Chlorocebus pygerythrus).
|
10662618 |
2000 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
HIV-1 V3 serotyping is used to classify immunodeficiency viruses on the basis of antibody binding to V3 peptides derived from env genetic subtypes.
|
9462924 |
1998 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
We conducted a genetic analysis and determined the amino acid signature patterns of the V3, V4, and V5 hypervariable domains and flanking regions in the HIV-1 gp120 env gene of 26 clones derived from proviral DNA in peripheral blood mononuclear cells of the members of the family. env sequences of the viruses isolated from the patients were compared with sequences of HIV-1 subtype B viruses from Europe and local field isolates.
|
9621043 |
1998 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Changes in the extracellular envelope glycoprotein of variants that evolve during the course of simian immunodeficiency virus SIVMne infection affect neutralizing antibody recognition, syncytium formation, and macrophage tropism but not replication, cytopathicity, or CCR-5 coreceptor recognition.
|
9420217 |
1998 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Passaging was begun with a chimeric virus containing the env gene of HIV-1 HXBc2 and the gag and pol genes of simian immunodeficiency virus SIVmac239.
|
8627799 |
1996 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Immunization trial of cats with a replication-defective adenovirus type 5 expressing the ENV gene of feline immunodeficiency virus.
|
7483252 |
1995 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Dimerization of the envelope glycoprotein precursor and dimeric forms of the transmembrane glycoproteins were also observed in cells infected with simian immunodeficiency virus (SIV-mac), a virus closely related to HIV-2.
|
2296088 |
1990 |