Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0281842
Disease: Abnormality of the fallopian tube
Abnormality of the fallopian tube 		0.100 Biomarker phenotype HPO
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 AlteredExpression group BEFREE Correlation of aberrant expression of p53, Rad50, and cyclin-E proteins with microsatellite instability in gallbladder adenocarcinomas. 19866438 2009
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group BEFREE Nevertheless, co-expression of Rad50, and cyclin-E with p53 was absent in adenomas with dysplasia, demonstrating their independent roles. 19866438 2009
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma 		0.010 Biomarker disease BEFREE These results suggest an influence of RAD50 and NBS1 on susceptibility to diffuse large B-cell lymphoma and marginal zone lymphoma. 19917125 2009
CUI: C0220605
Disease: Adult Non-Hodgkin Lymphoma
Adult Non-Hodgkin Lymphoma 		0.020 GeneticVariation disease BEFREE Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma. 17169801 2006
CUI: C0220605
Disease: Adult Non-Hodgkin Lymphoma
Adult Non-Hodgkin Lymphoma 		0.020 GeneticVariation disease BEFREE Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma. 19917125 2009
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.020 GeneticVariation disease BEFREE This study aimed to investigate whether the genetic polymorphisms of CDHR3 (rs6967330), GSDMB (rs2305480), IL33 rs928413, RAD50 (rs6871536) and IL1RL1 (rs1558641) are associated with the development of atopic asthma in Chinese population. 26493291 2015
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.020 GeneticVariation disease BEFREE Attempted replication of 50 reported asthma risk genes identifies a SNP in RAD50 as associated with childhood atopic asthma. 21734400 2011
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.100 GeneticVariation disease GWASCAT Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. 30013184 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease BEFREE Genomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated with total serum IgE levels and asthma. 24866380 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASCAT Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. 20159242 2010
CUI: C0004096
Disease: Asthma
Asthma 		0.480 Biomarker disease BEFREE Interestingly, these differences clustered in the genes highly associated with asthma (ORMDL family) and IgE regulation (RAD50, IL13, and IL4), but not in the T-regulatory genes (FOXP3, RUNX3). 23346934 2013
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASDB Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions. 20159242 2010
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease BEFREE Our findings first suggested that the variants in RAD50-IL13 region were not associated with asthma risk in Northeastern Han Chinese children. 26365633 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASDB Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. 21907864 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.480 Biomarker disease CTD_human Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma. 24241537 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.480 Biomarker disease BEFREE IL13, rather than RAD50, IL4, or IL5, is more likely to be the asthma susceptibility gene. 27050946 2016
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease BEFREE This is the first study validating that IL33, IL1R1, and RAD50 genes are associated with the risk of asthma in Chinese population. 26493291 2015
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASCAT Identification of Four Novel Loci in Asthma in European American and African American Populations. 27611488 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASCAT A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. 29785011 2018
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease BEFREE When adjusted for race and gender, only rs2706347 in RAD50 remained significantly associated with asthma. 21734400 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease BEFREE Polymorphisms within the RAD50 gene on chromosome 5q31 were consistently associated with IgE levels (P values 6.28 x 10(-7)-4.46 x 10(-8)) and increased the risk for atopic eczema and asthma. 18846228 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
CUI: C0004096
Disease: Asthma
Asthma 		0.480 GeneticVariation disease GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016