Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Identification of Four Novel Loci in Asthma in European American and African American Populations.
|
27611488 |
2017 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Our findings first suggested that the variants in RAD50-IL13 region were not associated with asthma risk in Northeastern Han Chinese children.
|
26365633 |
2016 |
Asthma
|
0.480 |
Biomarker
|
disease |
BEFREE |
IL13, rather than RAD50, IL4, or IL5, is more likely to be the asthma susceptibility gene.
|
27050946 |
2016 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
This is the first study validating that IL33, IL1R1, and RAD50 genes are associated with the risk of asthma in Chinese population.
|
26493291 |
2015 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Genomewide association and epigenetic studies found a region within the RAD50 gene on chromosome 5q31 to be associated with total serum IgE levels and asthma.
|
24866380 |
2014 |
Asthma
|
0.480 |
Biomarker
|
disease |
CTD_human |
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
|
24241537 |
2014 |
Asthma
|
0.480 |
Biomarker
|
disease |
BEFREE |
Interestingly, these differences clustered in the genes highly associated with asthma (ORMDL family) and IgE regulation (RAD50, IL13, and IL4), but not in the T-regulatory genes (FOXP3, RUNX3).
|
23346934 |
2013 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
When adjusted for race and gender, only rs2706347 in RAD50 remained significantly associated with asthma.
|
21734400 |
2011 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
|
20159242 |
2010 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
|
20159242 |
2010 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Multiple SNPs in the RAD50-IL13 region on chromosome 5q31.1 were associated with asthma: rs2244012 in intron 2 of RAD50 (P = 3.04E-07).
|
20159242 |
2010 |
Asthma
|
0.480 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms within the RAD50 gene on chromosome 5q31 were consistently associated with IgE levels (P values 6.28 x 10(-7)-4.46 x 10(-8)) and increased the risk for atopic eczema and asthma.
|
18846228 |
2008 |