Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
|
30013184 |
2018 |
Allergic Reaction
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
|
29083406 |
2017 |
Ulcerative Colitis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> The effects of DCZ0814 were evaluated in vitro using human MM cell lines (ARP1 and OCI-MY5) and in vivo in a murine xenograft MM model.
|
31213901 |
2019 |
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In ARP-1 and MM.1S tumor-bearing mice, repeat STRO-001 dosing provided significant antitumor activity with eradication of malignant hCD138+ BM plasma cells and prolonged survival.
|
30701025 |
2018 |
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We applied ND and MM-MSCs 72h secretomes to MM cell lines (U266 and ARP-1) for 12-72h and then assayed the cells' (viability, cell count, cell death, proliferation, cell cycle, autophagy) and TI (factors: eIF4E, teIF4GI; regulators: mTOR, MNK1/2, 4EBP; targets: cyclin D1, NFκB, SMAD5, cMyc, HIF1α).
|
26976208 |
2016 |
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Forced expression of bcl-2 in 8226 and ARP-1 multiple myeloma (MM) cell lines expressing relatively low levels of bcl-2, resulted in 1-2 log increase in resistance to dexamethasone (DEX)-induced apoptosis.
|
9454907 |
1998 |
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
High-yield, water-soluble, and purification-free MucoRice-ARP1 thus forms the basis for orally administered prophylaxis and therapy against rotavirus infections.
|
23925294 |
2013 |
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Previously we have shown that a recombinant monovalent antibody fragment (referred to as Anti-Rotavirus Proteins or ARP1) derived from a heavy chain antibody of a llama immunised with rotavirus was able to neutralise rotavirus infection in a mouse model system.
|
22403728 |
2012 |
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Orally administered MucoRice-ARP1 markedly decreased the viral load in immunocompetent and immunodeficient mice.
|
23925294 |
2013 |
Spinocerebellar Ataxia Type 5
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.
|
20603325 |
2010 |
Mesothelioma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Transcriptome sequencing of malignant pleural mesothelioma tumors.
|
18303113 |
2008 |
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene.
|
9539779 |
1998 |
Choriocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Co-transfection of an ARP-1 expression vector into BeWo choriocarcinoma cells, along with an expression vector containing 1.2 kb of the hPL promoter coupled to a CAT reporter gene, resulted in a dose-dependent inhibition of basal CAT activity.
|
8782080 |
1996 |
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1.
|
1321332 |
1992 |
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1.
|
1321332 |
1992 |