ACTR1A, actin related protein 1A, 10121

N. diseases: 12; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder)
0.100 GeneticVariation disease GWASCAT Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. 30013184 2018
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction
0.100 GeneticVariation phenotype GWASCAT Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. 29083406 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.100 GeneticVariation disease GWASCAT Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. 26192919 2015
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.040 Biomarker disease BEFREE <b>Methods:</b> The effects of DCZ0814 were evaluated in vitro using human MM cell lines (ARP1 and OCI-MY5) and in vivo in a murine xenograft MM model. 31213901 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.040 Biomarker disease BEFREE In ARP-1 and MM.1S tumor-bearing mice, repeat STRO-001 dosing provided significant antitumor activity with eradication of malignant hCD138+ BM plasma cells and prolonged survival. 30701025 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.040 Biomarker disease BEFREE We applied ND and MM-MSCs 72h secretomes to MM cell lines (U266 and ARP-1) for 12-72h and then assayed the cells' (viability, cell count, cell death, proliferation, cell cycle, autophagy) and TI (factors: eIF4E, teIF4GI; regulators: mTOR, MNK1/2, 4EBP; targets: cyclin D1, NFκB, SMAD5, cMyc, HIF1α). 26976208 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma
0.040 Biomarker disease BEFREE Forced expression of bcl-2 in 8226 and ARP-1 multiple myeloma (MM) cell lines expressing relatively low levels of bcl-2, resulted in 1-2 log increase in resistance to dexamethasone (DEX)-induced apoptosis. 9454907 1998
CUI: C0035869
Disease: Rotavirus Infections
Rotavirus Infections
0.020 Biomarker group BEFREE High-yield, water-soluble, and purification-free MucoRice-ARP1 thus forms the basis for orally administered prophylaxis and therapy against rotavirus infections. 23925294 2013
CUI: C0035869
Disease: Rotavirus Infections
Rotavirus Infections
0.020 Biomarker group BEFREE Previously we have shown that a recombinant monovalent antibody fragment (referred to as Anti-Rotavirus Proteins or ARP1) derived from a heavy chain antibody of a llama immunised with rotavirus was able to neutralise rotavirus infection in a mouse model system. 22403728 2012
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes
0.010 Biomarker group BEFREE Orally administered MucoRice-ARP1 markedly decreased the viral load in immunocompetent and immunodeficient mice. 23925294 2013
CUI: C0752123
Disease: Spinocerebellar Ataxia Type 5
Spinocerebellar Ataxia Type 5
0.010 GeneticVariation disease BEFREE Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi. 20603325 2010
CUI: C0025500
Disease: Mesothelioma
Mesothelioma
0.010 GeneticVariation disease LHGDN Transcriptome sequencing of malignant pleural mesothelioma tumors. 18303113 2008
CUI: C0085669
Disease: Acute leukemia
Acute leukemia
0.010 GeneticVariation disease BEFREE Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene. 9539779 1998
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma
0.010 AlteredExpression disease BEFREE Co-transfection of an ARP-1 expression vector into BeWo choriocarcinoma cells, along with an expression vector containing 1.2 kb of the hPL promoter coupled to a CAT reporter gene, resulted in a dose-dependent inhibition of basal CAT activity. 8782080 1996
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.010 Biomarker group BEFREE Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1. 1321332 1992
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.010 Biomarker disease BEFREE Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1. 1321332 1992