|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells.
|
17420453 |
2007 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells.
|
17420453 |
2007 |
|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, ERp5 was shown to be up-regulated in human surgical samples of invasive breast cancers.
|
17420453 |
2007 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells.
|
17420453 |
2007 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Moreover, ERp5, a closely related disulfide isomerase involved in major histocompatibility complex (MHC) class I chain-related protein A (MICA) shedding, also evoked potent humoral reactions in diverse solid and hematologic malignancy patients who responded to GM-CSF-secreting tumor cell vaccines or antibody blockade of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4).
|
19008459 |
2009 |
|
Hodgkin Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
|
22167753 |
2012 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we showed that S-nitrosylated P5 was present and the expression level of P5 was decreased in AD brains compared with that of control brains.
|
24037032 |
2014 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Changes in the expression of the protein disulfide isomerase genes PDIA3 and PDIA6 may increase endoplasmic reticulum stress, leading to cellular instability and neoplasia.
|
26125904 |
2015 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neuron-specific mapping of the genome-wide distribution of H3K4me3 revealed 136 differentially enriched loci associated with genes implicated in neuronal development and neurodegeneration, including GPR3, TMEM106B, PDIA6 and the Notch signaling genes hairy and enhancer of split 4 (HES4) and JAGGED2, supporting the view that the neuronal epigenome is affected in HD.
|
25480889 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The PDIA6 gene showed higher expression levels in the presence of lymph node metastasis (U = 99.00, P = 0.0476) and lower expression for negative hormone receptors status (P = 0.0351).
|
26125904 |
2015 |
|
Ductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the expression of PDIA3 and PDIA6 in invasive ductal carcinomas.
|
26125904 |
2015 |
|
Ductal Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PDIA3 and PDIA6 gene expression as an aggressiveness marker in primary ductal breast cancer.
|
26125904 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
RESULTS U87MG cell migration and invasion increased significantly after inhibition of PDIA6.
|
27540907 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
The in vitro study showed that PDIA6 downregulation significantly inhibited BC proliferation and invasion.
|
27760590 |
2017 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In summary, we showed that the levels of PDI and P5 were significantly decreased in the oligodendrocytes of AD patients.
|
28731225 |
2017 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, the in vivo experiment demonstrated that PDIA6 downregulation decreased the volume, weight, and metastasis of tumors.
|
27760590 |
2017 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest that PDIA6 could be targeted for the treatment of BC.
|
27760590 |
2017 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest that PDIA6 could be targeted for the treatment of BC.
|
27760590 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first report of the effects of PDIA6 on migration and invasion in glioblastoma.
|
27540907 |
2017 |
|
Giant Cell Tumor of Bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone.
|
28866093 |
2017 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first report of the effects of PDIA6 on migration and invasion in glioblastoma.
|
27540907 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first report of the effects of PDIA6 on migration and invasion in glioblastoma.
|
27540907 |
2017 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, we suggest that PDIA6 could be targeted for the treatment of BC.
|
27760590 |
2017 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first report of the effects of PDIA6 on migration and invasion in glioblastoma.
|
27540907 |
2017 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |