Glaucoma, Open-Angle
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
Glaucoma, Open-Angle
|
0.500 |
Biomarker
|
disease |
LHGDN |
Adult-onset primary open-angle glaucoma caused by mutations in optineurin.
|
11834836 |
2002 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The M98K variant of the OPTINEURIN (OPTN) gene modifies initial intraocular pressure in patients with primary open angle glaucoma.
|
14627677 |
2003 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Different optineurin mutation pattern in primary open-angle glaucoma.
|
12939304 |
2003 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The OPTN sequence variations were not significantly associated with any form of high-tension open-angle glaucoma.
|
14597044 |
2003 |
Glaucoma, Open-Angle
|
0.500 |
Biomarker
|
disease |
BEFREE |
Defining the pathogenicity of optineurin in juvenile open-angle glaucoma.
|
15326130 |
2004 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population.
|
15226658 |
2004 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To study the clinical relevance of sequence alterations in the optineurin gene (OPTN) among Japanese patients with open-angle glaucoma, including both primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG).
|
15370540 |
2004 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The optineurin (OPTN) gene has been reported to possess both causal as well as risk-associated alleles for open-angle glaucoma.
|
15498064 |
2004 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Defining the pathogenicity of optineurin in juvenile open-angle glaucoma.
|
15326130 |
2004 |
Glaucoma, Open-Angle
|
0.500 |
Biomarker
|
disease |
LHGDN |
Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma.
|
15557444 |
2004 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate the role of the common OPTN Met98Lys variant as a risk allele in open-angle glaucoma (OAG), autosomal dominant optic atrophy (ADOA) and Leber's hereditary optic neuropathy (LHON).
|
16885188 |
2006 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common polymorphisms in OLFM2 and OPTN may interactively contribute to the development of OAG, indicating a polygenic etiology.
|
17122126 |
2006 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Confirmation of the adult-onset primary open angle glaucoma locus GLC1B at 2cen-q13 in an Australian family.
|
16374045 |
2006 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Role of CYP1B1, MYOC, OPTN, and OPTC genes in adult-onset primary open-angle glaucoma: predominance of CYP1B1 mutations in Indian patients.
|
17563717 |
2007 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Optineurin coding variants in Ghanaian patients with primary open-angle glaucoma.
|
19096531 |
2008 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Absence of optineurin (OPTN) gene mutations in Taiwanese patients with juvenile-onset open-angle glaucoma.
|
18385781 |
2008 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.
|
18307994 |
2008 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A novel optineurin genetic mutation associated with open-angle glaucoma in a Chinese family.
|
19710941 |
2009 |
Glaucoma, Open-Angle
|
0.500 |
Biomarker
|
disease |
CTD_human |
Processing of optineurin in neuronal cells.
|
21059646 |
2011 |
Glaucoma, Open-Angle
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to determine to what extent variants within established genes (MYOC, OPTN, and WDR36) and newly identified common genetic variants (ATOH7, CDKN2B, and SIX1) contribute to the risk of OAG.
|
21872936 |
2011 |
Glaucoma, Open-Angle
|
0.500 |
Biomarker
|
disease |
CTD_human |
Optineurin associates with the podocyte Golgi complex to maintain its structure.
|
25096716 |
2014 |