Viral Load result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
Age at menarche
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
HIV-1, RESISTANCE TO
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
AIDS, PROGRESSION TO
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Association Between Single-Nucleotide Polymorphisms in HLA Alleles and Human Immunodeficiency Virus Type 1 Viral Load in Demographically Diverse, Antiretroviral Therapy-Naive Participants From the Strategic Timing of AntiRetroviral Treatment Trial.
|
31219150 |
2019 |
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
|
30224653 |
2018 |
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
Alcoholic Intoxication, Chronic
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
|
21529783 |
2011 |
Alcohol-Related Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
|
21529783 |
2011 |
Alcohol-Induced Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.
|
21529783 |
2011 |
MYOTONIC DYSTROPHY 1
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These findings unravel the mechanisms underlying the beneficial effects of MPH on cognitive deficits and depressive-like behaviors observed in Mbnl2 KO mice, and suggest that MPH could be a potential candidate to treat the CNS deficiencies in DM1 patients.
|
30060068 |
2019 |
MYOTONIC DYSTROPHY 1
|
0.040 |
Biomarker
|
disease |
BEFREE |
Intriguingly, the interaction of MBNL1 and MBNL2 is required to fully reverse the mis-splicing of Tau exon 2 induced by the trans-dominant effect of long CUG repeats, similar to the DM1 condition.
|
24440524 |
2014 |
MYOTONIC DYSTROPHY 1
|
0.040 |
Biomarker
|
disease |
BEFREE |
They also lend support to the hypothesis that the sequestration of this protein is an important determinant in DM pathophysiology, and imply a direct role of MBNL2 in splicing regulation of specific transcripts, which, when altered, contributes to the DM phenotype.
|
21303839 |
2011 |
MYOTONIC DYSTROPHY 1
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Small interfering RNA-mediated down-regulation of MBNL1, MBNL2, and CUG-BP in DM1 myoblasts demonstrated that MBNL1 plays a critical role in the maintenance of DM1 focus integrity.
|
15546872 |
2005 |
Myotonic Dystrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
MBNL2 binds directly to DM repeat expansions in the brain, resulting in depletion from its normal RNA targets with downstream effects on alternative splicing and polyadenylation.
|
26257173 |
2015 |
Myotonic Dystrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
We propose that major pathological features of the DM brain result from disruption of the MBNL2-mediated developmental splicing program.
|
22884328 |
2012 |
Myotonic Dystrophy
|
0.030 |
Biomarker
|
disease |
BEFREE |
Zebrafish deficient for Muscleblind-like 2 exhibit features of myotonic dystrophy.
|
21303839 |
2011 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MBNL2 overexpression mimicked the effect of NBT on breast cancer and lung cancer cell motility and metastasis, in addition significantly enhanced the inhibition effect of NBT.
|
31320607 |
2019 |
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
All these results indicated that MLP-1 can effectively inhibit renal fibrosis and potentially treat DN.
|
30521918 |
2019 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
MBNL2 knockdown furthermore partially eliminated the inhibitory effect of NBT on metastasis.
|
31320607 |
2019 |
Mood swings
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Methylphenidate Attenuates the Cognitive and Mood Alterations Observed in Mbnl2 Knockout Mice and Reduces Microglia Overexpression.
|
30060068 |
2019 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MBNL2 overexpression mimicked the effect of NBT on breast cancer and lung cancer cell motility and metastasis, in addition significantly enhanced the inhibition effect of NBT.
|
31320607 |
2019 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MBNL2 overexpression mimicked the effect of NBT on breast cancer and lung cancer cell motility and metastasis, in addition significantly enhanced the inhibition effect of NBT.
|
31320607 |
2019 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MBNL2 overexpression mimicked the effect of NBT on breast cancer and lung cancer cell motility and metastasis, in addition significantly enhanced the inhibition effect of NBT.
|
31320607 |
2019 |