|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NFκB Activation in Breast Cancer.
|
25837675 |
2015 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of fascin-1 and MAP17 was assessed via immunohistochemistry in surgical specimens of a cohort comprised of 127 patients with resectable breast cancer.
|
31273628 |
2019 |
|
Thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Quantitative RT-PCR showed that HS6ST2, COL1A1, F2RL1, LEPREL1, PDZK1, and PDZK1IP1 are overexpressed in thyroid carcinoma samples compared with normal thyroids.
|
24848707 |
2014 |
|
Thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, we show that aberrant promoter hypomethylation-associated overexpression of MAP17 might promote tumor growth in thyroid cancer.
|
23666970 |
2013 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Expression of fascin-1 and MAP17 was assessed via immunohistochemistry in surgical specimens of a cohort comprised of 127 patients with resectable breast cancer.
|
31273628 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
MAP17 (PDZKIP1) Expression Determines Sensitivity to the Proteasomal Inhibitor Bortezomib by Preventing Cytoprotective Autophagy and NFκB Activation in Breast Cancer.
|
25837675 |
2015 |
|
Atrial Fibrillation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Paroxysmal AF comparing to permanent AF and SR individuals had higher estimated SPAP (56 versus 48 versus 47 mmHg, <i>p</i> = 0.01) and shorter ACT (58 versus 65 versus 70 ms, <i>p</i> = 0.04).
|
28280732 |
2017 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we show that aberrant promoter hypomethylation-associated overexpression of MAP17 might promote tumor growth in thyroid cancer.
|
23666970 |
2013 |
|
Noninfiltrating Intraductal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the expression of DD96 is induced in immortalized breast ductal epithelial cell lines compared with normal breast ductal epithelial cells, and, in vivo, in premalignant conditions, such as adenoma of the colon and ductal carcinoma in situ of the breast.
|
9815914 |
1995 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Certain cancer-related genes such as DD96, DRAL and MXI1 were differentially expressed only in UC.
|
11181568 |
2001 |
|
Dental caries
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Detection of Streptococcus mutans by PCR amplification of the spaP gene in teeth rendered caries free.
|
9699435 |
1998 |
|
Dermatitis, Atopic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, MAP17 was originally reported to interact with PDZK1; in turn, the PDZK1 gene is localized within the atopic dermatitis-linked region on human chromosome 1q21.
|
19601982 |
2010 |
|
Eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, MAP17 was originally reported to interact with PDZK1; in turn, the PDZK1 gene is localized within the atopic dermatitis-linked region on human chromosome 1q21.
|
19601982 |
2010 |
|
Mesothelioma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Transcriptome sequencing of malignant pleural mesothelioma tumors.
|
18303113 |
2008 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
To analyze whether MAP17 could also alter this process, we used the proteasome inhibitor bortezomib (Velcade, PS-341), which is approved for the treatment of multiple myeloma and mantle cell lymphoma, although it has a high rate of resistance emergence and poor efficacy in solid tumors.
|
25837675 |
2015 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry confirms local inflammation, mainly CD45<sup>+</sup> cells, at the site of expression of MAP17, at least in tumors, Crohn's and psoriasis.
|
29228712 |
2017 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we show that aberrant promoter hypomethylation-associated overexpression of MAP17 might promote tumor growth in thyroid cancer.
|
23666970 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, we show that MAP17 expression predicts proteasome inhibitor efficacy in this context and that bortezomib, an FDA-approved drug, may be a novel therapeutic approach for MAP17-overexpressing lung adenocarcinomas.
|
30119639 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively these findings suggest that MAP17 serves a role in TKI resistance through regulation of CSCs in lung cancer.
|
29616128 |
2018 |
|
Caries (morphologic abnormality)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Detection of Streptococcus mutans by PCR amplification of the spaP gene in teeth rendered caries free.
|
9699435 |
1998 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
To analyze whether MAP17 could also alter this process, we used the proteasome inhibitor bortezomib (Velcade, PS-341), which is approved for the treatment of multiple myeloma and mantle cell lymphoma, although it has a high rate of resistance emergence and poor efficacy in solid tumors.
|
25837675 |
2015 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential gene expression analysis demonstrated significant upregulation of PDZK1IP1, EEF1A2 and RPL41 (ENSG00000279483) genes in the iCCA samples when compared with the matched para‑tumor samples.
|
27082702 |
2016 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively these findings suggest that MAP17 serves a role in TKI resistance through regulation of CSCs in lung cancer.
|
29616128 |
2018 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical analysis of MAP17 during cancer progression shows, at least in prostate and ovarian carcinomas, that overexpression of the protein strongly correlates with tumoral progression (P < 0.0001).
|
17426052 |
2007 |