PDZK1IP1, PDZK1 interacting protein 1, 10158

N. diseases: 46; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011334
Disease: Dental caries
Dental caries 		0.010 GeneticVariation disease BEFREE Detection of Streptococcus mutans by PCR amplification of the spaP gene in teeth rendered caries free. 9699435 1998
CUI: C0333519
Disease: Caries (morphologic abnormality)
Caries (morphologic abnormality) 		0.010 GeneticVariation disease BEFREE Detection of Streptococcus mutans by PCR amplification of the spaP gene in teeth rendered caries free. 9699435 1998
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE In addition, DD96 is overexpressed markedly in various human carcinomas originating from the colon, breast, and lung, as well as in a number of cell lines derived from tumors of these organs compared with normal epithelial cell populations. 9815914 1995
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.070 AlteredExpression group BEFREE In addition, DD96 is overexpressed markedly in various human carcinomas originating from the colon, breast, and lung, as well as in a number of cell lines derived from tumors of these organs compared with normal epithelial cell populations. 9815914 1995
CUI: C0007124
Disease: Noninfiltrating Intraductal Carcinoma
Noninfiltrating Intraductal Carcinoma 		0.010 AlteredExpression disease BEFREE Furthermore, the expression of DD96 is induced in immortalized breast ductal epithelial cell lines compared with normal breast ductal epithelial cells, and, in vivo, in premalignant conditions, such as adenoma of the colon and ductal carcinoma in situ of the breast. 9815914 1995
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions 		0.010 AlteredExpression group BEFREE Furthermore, the expression of DD96 is induced in immortalized breast ductal epithelial cell lines compared with normal breast ductal epithelial cells, and, in vivo, in premalignant conditions, such as adenoma of the colon and ductal carcinoma in situ of the breast. 9815914 1995
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.010 Biomarker phenotype BEFREE These results suggest that DD96 may play a role in the early events associated with malignant transformation; however, its function remains to be determined. 9815914 1995
CUI: C4551463
Disease: Colon adenoma
Colon adenoma 		0.010 AlteredExpression disease BEFREE Furthermore, the expression of DD96 is induced in immortalized breast ductal epithelial cell lines compared with normal breast ductal epithelial cells, and, in vivo, in premalignant conditions, such as adenoma of the colon and ductal carcinoma in situ of the breast. 9815914 1995
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.070 AlteredExpression group BEFREE Using in situ hybridization, we demonstrated that MAP17 and PDZK1 mRNAs are markedly up-regulated in human carcinomas. 10496535 1999
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE Therefore, the protein cluster formed by the association of cMOAT, PDZK1, and MAP17 could play an important role in the cellular mechanisms associated with multidrug resistance, and PDZK1 may represent a new target in cancer cells resistant to chemotherapeutic agents. 10496535 1999
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 Biomarker group BEFREE Therefore, the protein cluster formed by the association of cMOAT, PDZK1, and MAP17 could play an important role in the cellular mechanisms associated with multidrug resistance, and PDZK1 may represent a new target in cancer cells resistant to chemotherapeutic agents. 10496535 1999
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.010 AlteredExpression disease BEFREE Certain cancer-related genes such as DD96, DRAL and MXI1 were differentially expressed only in UC. 11181568 2001
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.300 Biomarker group CTD_human Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model. 17013881 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.300 Biomarker disease CTD_human Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model. 17013881 2007
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 Biomarker group BEFREE CIMP-H (>1 marker positive) was significantly more frequent in SPAP, SA, and SCa compared with MVSP (P<0.05); CIMP-H was present in 10% of sTAs but was found more frequently in lTA (44.4%; OR 7.2; P=0.007) and TCa (38.9%; OR 5.8; P=0.007). 17122504 2006
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.070 AlteredExpression group BEFREE Taken together, our data show an independent activation of MAP17 promoter that can be driven by oncogenes and that might explain the common overexpression of MAP17 in human carcinomas. 17426052 2007
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.030 Biomarker phenotype BEFREE Immunohistochemical analysis of MAP17 during cancer progression shows, at least in prostate and ovarian carcinomas, that overexpression of the protein strongly correlates with tumoral progression (P < 0.0001). 17426052 2007
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.010 Biomarker disease BEFREE Immunohistochemical analysis of MAP17 during cancer progression shows, at least in prostate and ovarian carcinomas, that overexpression of the protein strongly correlates with tumoral progression (P < 0.0001). 17426052 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.070 AlteredExpression group BEFREE We identified MAP17, a small 17 kDa non-glycosylated membrane protein previously identified by differential display being over-expressed in carcinomas. 17548903 2007
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 Biomarker phenotype BEFREE Finally, we show that MAP17-dependent ROS increase and tumorigenesis are dependent on its PDZ-binding domain, since disruption of its sequence by point mutations abolishes its ability to enhance ROS production and tumorigenesis. 17548903 2007
CUI: C0025500
Disease: Mesothelioma
Mesothelioma 		0.010 GeneticVariation disease LHGDN Transcriptome sequencing of malignant pleural mesothelioma tumors. 18303113 2008
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.010 Biomarker disease BEFREE Interestingly, MAP17 was originally reported to interact with PDZK1; in turn, the PDZK1 gene is localized within the atopic dermatitis-linked region on human chromosome 1q21. 19601982 2010
CUI: C0013595
Disease: Eczema
Eczema 		0.010 Biomarker disease BEFREE Interestingly, MAP17 was originally reported to interact with PDZK1; in turn, the PDZK1 gene is localized within the atopic dermatitis-linked region on human chromosome 1q21. 19601982 2010
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.010 AlteredExpression group BEFREE Taken together, the Th cell cytokine-induced up-regulation of MAP17 expression may be linked to the down-regulation of filaggrin in NHEK, which may be associated with the abnormal epidermal differentiation observed in the dermatological diseases. 19601982 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.080 AlteredExpression group BEFREE We have found that MAP17 is expressed in 60% human mammary tumors while it is not expressed in normal or benign neoplasias. 22266858 2012