|
Lymphoproliferative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Treatment with alsterpaullone, an inhibitor of the CDK2 complex, resulted in a survival benefit and suppressed tumor invasion in a mouse model of LPDs.
|
31743514 |
2020 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To gain insight into the molecular implication of CDK2 and CDK4 kinases in psoriasis, we sought to characterize expression of these kinases and associated cyclins, as well as of CKIs, and addressed the status of CDK2 and CDK4 activity in human psoriatic epidermis.
|
31145809 |
2020 |
|
Endometriosis of uterus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that mifepristone causes cell cycle arrest through inhibiting CDK1 and CDK2 expressions and induces cell apoptosis via the mitochondria-dependent signalling pathway in endometrial epithelial cells and stromal cells of adenomyosis.
|
31814282 |
2020 |
|
Ewings sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of the ATR-CHK1 Pathway in Ewing Sarcoma Cells Causes DNA Damage and Apoptosis via the CDK2-Mediated Degradation of RRM2.
|
31649026 |
2020 |
|
Polyostotic fibrous dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDK2 protein expression was clearly decreased in PFD-treated LNCaP and PC-3 cells, whereas p21 protein expression was increased in only PFD-treated LNCaP cells.
|
30621175 |
2019 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Gephyrin overexpression suppressed LUSC cell proliferation, arrested cell cycle progression, and decreased the expression of cell-cycle related proteins such as cyclin D1, cyclin-dependent kinase-2 (CDK2), and proliferation-related protein proliferating cell nuclear antigen (PCNA).
|
31239782 |
2019 |
|
Non-Functioning Pituitary Gland Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
High NR2C2 expression was associated with NFPA invasion, recurrence, and progression, while TBX19 and CDK2 were associated with NFPA recurrence.
|
31223310 |
2019 |
|
Poikiloderma of Kindler
|
0.010 |
Biomarker
|
disease |
BEFREE |
CDK1 and CDK2 are key regulators of cell cycle progression, however, cell cycle analysis showed only small differences between the KS and KS-Kin1WT keratinocytes.
|
31260568 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Given the frequent association of CCNE1 amplification with liver metastasis, close follow up for liver metastasis and further clinical trials targeting CDK2 inhibitors are warranted.
|
31178228 |
2019 |
|
PROPERDIN DEFICIENCY, X-LINKED
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDK2 protein expression was clearly decreased in PFD-treated LNCaP and PC-3 cells, whereas p21 protein expression was increased in only PFD-treated LNCaP cells.
|
30621175 |
2019 |
|
Deuteranomaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further investigation showed that CBD significantly upregulated ataxia telangiectasia-mutated gene (ATM) and p53 protein expression and downregulated p21 protein expression in SGC-7901 cells, which subsequently inhibited the levels of CDK2 and cyclin E, thereby resulting in cell cycle arrest at the G0-G1 phase.
|
31349651 |
2019 |
|
Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that AS-IV exerted beneficial effects on AngII -induced abnormal growth in rat VSMCs through disturbing cell cycle, especially block G1/S transition by attenuating CDK2 activity, which may hinder the process of pathological vascular remodeling during atherosclerosis.
|
29567075 |
2018 |
|
Atherosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggested that AS-IV exerted beneficial effects on AngII -induced abnormal growth in rat VSMCs through disturbing cell cycle, especially block G1/S transition by attenuating CDK2 activity, which may hinder the process of pathological vascular remodeling during atherosclerosis.
|
29567075 |
2018 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
After the establishment of rat models of IDD for the measurement of positive expression of SUMO2/3 protein, the mRNA and protein levels of SUMO2, molecular phenotype [matrix metalloproteinase-2 (MMP-2) and hypoxia-inducible factor-1α (HIF-1α)] and p53 signaling pathway-related genes [p21, murine double minute-2 (MDM2), growth arrest and DNA-damage-inducible protein 45 α (GADD45α), cyclin-dependent kinase 2/4 (CDK2/4), and CyclinB1] were determined, followed by the detection of cell proliferation, cell cycle, apoptosis, and cell senescence.
|
29700214 |
2018 |
|
Acute monocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2.
|
29720484 |
2018 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
|
29511348 |
2018 |
|
Oligospermia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To examine whether mutations of the CDK2 gene exist in Chinese men with non-obstructive azoospermia (NOA) with different histopathology, we recruited 175 Chinese men with idiopathic NOA who underwent testis biopsy, including hypospermatogenesis, germ cell maturation arrest and Sertoli cell only syndrome.
|
29373224 |
2018 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
OA-treated DU145 cells were arrested in G2 because of the activation of p-AKT, p-JNK, p21 and p27, and the decrease in p-ERK, cyclin B1 and CDK2 expression; OA-treated MCF-7 cells were arrested in G1 owing to the activation of p-JNK, p-ERK, p21, and p27, and the decrease in p-AKT, cyclin D1, CDK4, cyclin E, and CDK2; and OA-treated U87 cells also exhibited G1 phase arrest caused by the increase in p-ERK, p-JNK, p-AKT, p21, and p27, and the decrease in cyclin D1, CDK4, cyclin E and CDK2.
|
29899865 |
2018 |
|
Intervertebral disc disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
After the establishment of rat models of IDD for the measurement of positive expression of SUMO2/3 protein, the mRNA and protein levels of SUMO2, molecular phenotype [matrix metalloproteinase-2 (MMP-2) and hypoxia-inducible factor-1α (HIF-1α)] and p53 signaling pathway-related genes [p21, murine double minute-2 (MDM2), growth arrest and DNA-damage-inducible protein 45 α (GADD45α), cyclin-dependent kinase 2/4 (CDK2/4), and CyclinB1] were determined, followed by the detection of cell proliferation, cell cycle, apoptosis, and cell senescence.
|
29700214 |
2018 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of CK7 and CDKN2 in Cervical Intraepithelial Neoplasia and Correlation with Clinical Outcome.
|
30504376 |
2018 |
|
Childhood Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
|
29511348 |
2018 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma.
|
29511348 |
2018 |
|
Hematopoietic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This finding suggested that inhibition of CDK2 and pRb expression via upregulated p21 was involved in the downregulation of Pim-2-induced G<sub>0</sub>/G<sub>1</sub> cell cycle arrest in lung cancer and hematopoietic malignancy cells.
|
29541172 |
2018 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
As serine/threonine kinase, the cyclin dependent kinase 2 (CDK2) is a promising target for various diseases such as cerebral hypoxia, cancer, and neurodegenerative diseases.
|
30197029 |
2018 |
|
Enzyme inhibition disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
They were then evaluated using CDK2-CyclinA2 enzyme inhibition by a luminescent ADP detection assay.
|
29767460 |
2018 |